[PDF][PDF] A cellular taxonomy of the adult human spinal cord

A Yadav, KJE Matson, L Li, I Hua, J Petrescu, K Kang… - Neuron, 2023 - cell.com
The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …

Axonal growth inhibitors and their receptors in spinal cord injury: from biology to clinical translation

SS Chambel, CD Cruz - Neural Regeneration Research, 2023 - journals.lww.com
Axonal growth inhibitors are released during traumatic injuries to the adult mammalian
central nervous system, including after spinal cord injury. These molecules accumulate at …

Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury

Y Fan, X Wu, S Han, Q Zhang, Z Sun, B Chen… - Nature …, 2023 - nature.com
Spinal cord injury (SCI) leads to severe sensory and motor dysfunction below the lesion.
However, the cellular dynamic responses and heterogeneity across different regions below …

Age-dependent immune and lymphatic responses after spinal cord injury

AFM Salvador, T Dykstra, J Rustenhoven, W Gao… - Neuron, 2023 - cell.com
Spinal cord injury (SCI) causes lifelong debilitating conditions. Previous works demonstrated
the essential role of the immune system in recovery after SCI. Here, we explored the …

[PDF][PDF] Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration

HJ Kim, JM Saikia, KMA Monte, E Ha… - Neuron, 2023 - cell.com
Despite substantial progress in understanding the biology of axon regeneration in the CNS,
our ability to promote regeneration of the clinically important corticospinal tract (CST) after …

[HTML][HTML] Targeting Mitochondrial Oxidative Stress: Potential Neuroprotective Therapy for Spinal Cord Injury

Z He, C Zhang, JX Liang, FF Zheng, XY Qi… - Journal of Integrative …, 2023 - imrpress.com
Spinal cord injury (SCI) is a serious central nervous system (CNS) injury disease related to
hypoxia-ischemia and inflammation. It is characterized by excessive reactive oxygen …

Single-nucleus transcriptomic mapping uncovers targets for traumatic brain injury

Q Yang, L Zhang, M Li, Y Xu, X Chen, R Yuan… - Genome …, 2023 - genome.cshlp.org
The subventricular zone (SVZ) is a neurogenic niche that contributes to homeostasis and
repair after brain injury. However, the effects of mild traumatic brain injury (mTBI) on the …

Diurnal proteome profile of the mouse cerebral cortex: Conditional deletion of the Bmal1 circadian clock gene elevates astrocyte protein levels and cell abundance in …

T Bering, C Gadgaard, H Vorum, B Honoré, MF Rath - Glia, 2023 - Wiley Online Library
Circadian oscillators, defined by cellular 24 h clock gene rhythms, are found throughout the
brain. Cerebral cortex‐specific conditional knockout of the clock gene Bmal1 (Bmal1 CKO) …

Zinc regulates a specific subpopulation of VEGFA+ microglia to improve the hypoxic microenvironment for functional recovery after spinal cord injury

H Deng, Y Liu, Z Shi, J Yang, C Liu, X Mei - International …, 2023 - Elsevier
Introduction Spinal cord injury (SCI) is a central nervous system injury that is primarily
traumatic and manifests as autonomic dysfunction below the level of injury. Our previous …

Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11. 2 duplication

Y Hasegawa, J Kim, G Ursini, Y Jouroukhin… - Nature …, 2023 - nature.com
Adolescent cannabis use increases the risk for cognitive impairments and psychiatric
disorders. Cannabinoid receptor type 1 (Cnr1) is expressed not only in neurons and …