For most genes, mRNA transcript abundance scales with cell size to ensure a constant
concentration. Scaling of mRNA synthesis rates with cell size plays an important role, with …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Imaging-based methods are widely used for studying the subcellular localization of proteins
in living cells. While routine for individual proteins, global monitoring of protein dynamics …

Assessing the impact of SARS-CoV-2 on organelle dynamics allows a better understanding
of the mechanisms of viral replication. We combine label-free holotomographic microscopy …

Spatial omics technologies decipher functional components of complex organs at cellular
and subcellular resolutions. We introduce Spatial Graph Fourier Transform (SpaGFT) and …

The spatial organization of molecules in a cell is essential for their functions. While current
methods focus on discerning tissue architecture, cell–cell interactions, and spatial …

Abstract RNA polymerase II (Pol II) is the multi-protein complex responsible for transcribing
all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on …

The mammalian cell is a complex entity, with membrane-bound and membrane-less
organelles playing vital roles in regulating cellular homeostasis. Organellar protein niches …

Amine-reactive esters of aromatic fluorescent dyes are emerging as imaging probes for
nondescript staining of cellular and tissue architectures. We characterised the staining …

Abstract Cyclic Immunofluorescence (CyCIF) can quantify multiple biomarkers, but panel
capacity is limited by technical challenges. We propose a computational panel reduction …