Doxorubicin (DOX) is a chemotherapeutic agent frequently used for the treatment of a variety
of tumor types, such as breast cancer. Despite the long history of DOX, the mechanistic …

The field of nanotechnology, through which nanomaterials are designed, characterized,
produced, and applied, is rapidly emerging in various fields, including energy, electronics …

Accumulating evidence indicates a correlation between circadian dysfunction and genomic
instability. However, whether the circadian machinery directly regulates DNA damage repair …

Hydroxyl radical (HO•) is the most reactive toward DNA among the reactive oxygen species
(ROS) generated in aerobic organisms by cellular metabolisms. HO• is generated also by …

The allure of tobacco smoking is linked to the instant gratification provided by inhaled
nicotine. Unfortunately, tobacco curing and burning generates many mutagens including …

Radiation-induced foci (RIF) are nuclear puncta visualized by immunostaining of proteins
that regulate DNA double-strand break (DSB) repair after exposure to ionizing radiation. RIF …

This optimized protocol (including links to instruction videos) describes a comet-based in
vitro DNA repair assay that is relatively simple, versatile, and inexpensive, enabling the …

Background: Oxidative stress plays a critical role in lung cancer progression. Carotenoids
are efficient antioxidants. The objective of this study was to explore the efficacy of all-trans …

The review includes information on the current state of knowledge of immunometric methods
with emphasis on the possibility of deoxyribonucleic acid (DNA) damage detection …

Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which
require enormous resources in both money and time. In silico models have been developed …