T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
Coreceptors and TCR signaling–the strong and the weak of it
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic
development, but how they contribute to immune responses in the periphery is unclear …
development, but how they contribute to immune responses in the periphery is unclear …
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation
C Guy, DM Mitrea, PC Chou, J Temirov, KM Vignali… - Nature …, 2022 - nature.com
LAG3 is an inhibitory receptor that is highly expressed on exhausted T cells. Although LAG3-
targeting immunotherapeutics are currently in clinical trials, how LAG3 inhibits T cell function …
targeting immunotherapeutics are currently in clinical trials, how LAG3 inhibits T cell function …
Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling
INTRODUCTION T cell receptor (TCR) recognition of peptide–major histocompatibility
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells
The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen
receptor (TCR) signaling machinery, leading to key T cell fate decisions. Despite decades of …
receptor (TCR) signaling machinery, leading to key T cell fate decisions. Despite decades of …
Lck bound to coreceptor is less active than free Lck
Q Wei, J Brzostek, S Sankaran… - Proceedings of the …, 2020 - National Acad Sciences
Src family kinase Lck plays critical roles during T cell development and activation, as it
phosphorylates the TCR/CD3 complex to initiate TCR signaling. Lck is present either in …
phosphorylates the TCR/CD3 complex to initiate TCR signaling. Lck is present either in …
Immune system changes in those with hypertension when infected with SARS-CoV-2
S Su, R Chen, S Zhang, H Shu, J Luo - Cellular Immunology, 2022 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) outbreak has become an evolving
global health crisis. With an increasing incidence of primary hypertension, there is greater …
global health crisis. With an increasing incidence of primary hypertension, there is greater …
Helminth Infection–Induced Increase in Virtual Memory CD8 T Cells Is Transient, Driven by IL-15, and Absent in Aged Mice
Abstract CD8 virtual memory T (T VM) cells are Ag-naive CD8 T cells that have undergone
partial differentiation in response to common γ-chain cytokines, particularly IL-15 and IL-4. T …
partial differentiation in response to common γ-chain cytokines, particularly IL-15 and IL-4. T …
Mathematical models of TCR initial triggering
J Shi, W Yin, W Chen - Frontiers in Immunology, 2024 - frontiersin.org
T cell receptors (TCRs) play crucial roles in regulating T cell response by rapidly and
accurately recognizing foreign and non-self antigens. The process involves multiple …
accurately recognizing foreign and non-self antigens. The process involves multiple …
Tyrosine kinase inhibitors and atherosclerosis: a close but complicated relationship
K Xu, H Tang, J Xiong, X Ban, Y Duan, Y Tu - European Journal of …, 2023 - Elsevier
Targeted cancer therapies have revolutionized the treatment of the disease in the past
decade. The tyrosine kinase inhibitor (TKI) class of drugs is a widely used option for treating …
decade. The tyrosine kinase inhibitor (TKI) class of drugs is a widely used option for treating …