Background Aquaporin (AQP) water channels are best known as passive transporters of
water that are vital for water homeostasis. Scope of review AQP knockout studies in whole …

Congenital cataracts, the most common cause of visual impairment and blindness in
children worldwide, have diverse etiologies. According to statistics analysis, about one …

The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …

Aquaporin (AQP) water channels are pivotal to renal water handling and therefore in the
regulation of body water homeostasis. However, beyond the kidney, AQPs facilitate water …

Aquaporins are tetrameric membrane-bound channels that facilitate transport of water and
other small solutes across cell membranes. In eukaryotes, they are frequently regulated by …

Cataract and presbyopia are the leading cause of vision loss and impaired vision,
respectively, worldwide. Changes in lens biochemistry and physiology with age are …

The pathogenesis of congenital cataract (CC), a major disease associated with blindness in
infants, is complex and diverse. Aquaporin 5 (AQP5) represents an essential membrane …

Aquaporins (AQPs) function as tetrameric structures in which each monomer has its own
permeable pathway. The combination of structural biology, molecular dynamics simulations …

Ionizing radiation is a proven human carcinogen and cataractogen. The crystalline lens of
the eye is among the most radiosensitive tissues in the body. A clouding of the normally …

Lens, an avascular organ involved in light transmission, contains an internal micro-
circulatory system coupling ions to fluid movement, thus providing nutrients to internal lens …