Advances and utility of the human plasma proteome

EW Deutsch, GS Omenn, Z Sun, M Maes… - Journal of proteome …, 2021 - ACS Publications
The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …

Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

J Montaner, L Ramiro, A Simats, S Tiedt… - Nature Reviews …, 2020 - nature.com
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …

Mass spectrometry-based plasma proteomics: considerations from sample collection to achieving translational data

V Ignjatovic, PE Geyer, KK Palaniappan… - Journal of proteome …, 2019 - ACS Publications
The proteomic analysis of human blood and blood-derived products (eg, plasma) offers an
attractive avenue to translate research progress from the laboratory into the clinic. However …

Stroke proteomics: from discovery to diagnostic and therapeutic applications

K Hochrainer, W Yang - Circulation research, 2022 - Am Heart Assoc
Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Sex differences in presentation and outcome after an acute transient or minor neurologic event

YX Amy, AM Penn, ML Lesperance, NS Croteau… - JAMA …, 2019 - jamanetwork.com
Importance Sex differences have been described in the presentation, care, and outcomes
among people with acute ischemic strokes, but these differences are less understood for …

Proteomics in thrombosis and hemostasis

N Letunica, S Van Den Helm… - Thrombosis and …, 2022 - thieme-connect.com
Proteomics, the simultaneous study of all proteins in a given cell, tissue or organism, is an
innovative approach used to identify novel markers for diagnosis, prognosis and the …

[HTML][HTML] Multiplex quantitation of 270 plasma protein markers to identify a signature for early detection of colorectal cancer

M Bhardwaj, K Weigl, K Tikk, T Holland-Letz… - European Journal of …, 2020 - Elsevier
Blood-based protein biomarker signatures might be an alternative or supplement to existing
methods for early detection of colorectal cancer (CRC) for population-based screening. The …

Association between duration of transient neurological events and diffusion‐weighted brain lesions

RA Joundi, AYX Yu, EE Smith, C Zerna… - Journal of the …, 2023 - Am Heart Assoc
Background The relationship between duration of transient neurological events and
presence of diffusion‐weighted lesions by symptom type is unclear. Methods and Results …

Biobanking for genomic and personalized health research: participant perceptions and preferences

R Barnes, K Votova, V Rahimzadeh… - Biopreservation and …, 2020 - liebertpub.com
Introduction: Biospecimens and associated data are invaluable tools in Genomics and
Personalized Health (GAPH) research and can aid in the discovery of disease etiology and …

Presenting Symptoms and Diffusion-Weighted MRI Positivity by Time After Transient Neurologic Events: A Pooled Analysis of 3 Cohort Studies

K Tanaka, SB Coutts, RA Joundi, N Singh, T Uehara… - Neurology, 2024 - AAN Enterprises
Background and Objective The association between focal vs nonfocal presenting symptom
and diffusion-weighted imaging (DWI) positivity in relation to onset-to-imaging time in …