The biophysics and cell biology of lipid droplets

AR Thiam, RV Farese Jr, TC Walther - Nature reviews Molecular cell …, 2013 - nature.com
Lipid droplets are intracellular organelles that are found in most cells, where they have
fundamental roles in metabolism. They function prominently in storing oil-based reserves of …

The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer

MM Kaczmarczyk, MJ Miller, GG Freund - Metabolism, 2012 - Elsevier
Dietary fiber (DF) is deemed to be a key component in healthy eating. DF is not a static
collection of undigestible plant materials that pass untouched or unencumbered through the …

Recent advances in hepatocellular carcinoma therapy

R Dutta, RI Mahato - Pharmacology & therapeutics, 2017 - Elsevier
Hepatocellular carcinoma (HCC), also called malignant hepatoma, is one of the deadliest
cancers due to its complexities, reoccurrence after surgical resection, metastasis and …

Yarrowia lipolytica as a model for bio-oil production

A Beopoulos, J Cescut, R Haddouche… - Progress in lipid …, 2009 - Elsevier
The yeast Yarrowialipolytica has developed very efficient mechanisms for breaking down
and using hydrophobic substrates. It is considered an oleaginous yeast, based on its ability …

Not just fat: the structure and function of the lipid droplet

T Fujimoto, RG Parton - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Lipid droplets (LDs) are independent organelles that are composed of a lipid ester core and
a surface phospholipid monolayer. Recent studies have revealed many new proteins …

[HTML][HTML] Autophagy, lipophagy and lysosomal lipid storage disorders

C Ward, N Martinez-Lopez, EG Otten, B Carroll… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Autophagy is a catabolic process with an essential function in the maintenance of cellular
and tissue homeostasis. It is primarily recognised for its role in the degradation of …

An Overview of Hormone‐Sensitive Lipase (HSL)

AR Althaher - The Scientific World Journal, 2022 - Wiley Online Library
Hormone‐sensitive lipase (HSL) is a pivotal enzyme that mediates triglyceride hydrolysis to
provide free fatty acids and glycerol in adipocytes in a hormonally controlled lipolysis …

[HTML][HTML] Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation

EP Mottillo, P Balasubramanian, YH Lee, C Weng… - Journal of lipid …, 2014 - ASBMB
Chronic activation of β3-adrenergic receptors (β3-ARs) expands the catabolic activity of both
brown and white adipose tissue by engaging uncoupling protein 1 (UCP1)-dependent and …

[HTML][HTML] A twist of FATe: Lipid droplets and inflammatory lipid mediators

E Jarc, T Petan - Biochimie, 2020 - Elsevier
Lipid droplets are fat storage organelles present in most eukaryotic cells. They consist of a
neutral lipid core containing mostly triglycerides and sterol esters and covered by a …

[HTML][HTML] The G0/G1 switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase

X Yang, X Lu, M Lombès, GB Rha, YI Chi, TM Guerin… - Cell metabolism, 2010 - cell.com
Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme for triacylglycerol (TAG)
hydrolysis in adipocytes. The precise mechanisms whereby ATGL is regulated remain …