Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

Hypoxia is a condition commonly observed in the core of solid tumors. The hypoxia-
inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response …

Cancer cells exhibit unregulated growth, altered metabolism, enhanced metastatic potential
and altered cell surface glycans. Fueled by oncometabolism and elevated uptake of glucose …

Developing drug delivery carriers for highly selective, controlled, and sustained release of
the anti-cancer drugs is one of the crucial issues in the cancer strive. We herein report the …

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths in the world.
Drug resistance of tumour cells remains the main challenge toward curative treatments …

The cancer burden continues to grow globally, and drug resistance remains a substantial
challenge in cancer therapy. It is well established that cancerous cells with clonal dysplasia …

The incidence of thyroid cancer is growing rapidly during the past decades worldwide.
Although most thyroid tumors are curable, some patients diagnosed with distant metastases …

Lung cancer is the leading cause of cancer-related death worldwide. MicroRNAs (miRNAs)
in circulating small extracellular vesicles (sEVs) have been suggested to be potential …

Objective—Calcific aortic valve (AV) disease, characterized by AV sclerosis and
calcification, is a major cause of death in the aging population; however, there are no …

Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation), a dynamic post-
translational modification (PTM), holds profound implications in controlling various cellular …