The rapid emergence of antifungal-resistant human-pathogenic fungi

SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …

Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

J Rhodes, A Abdolrasouli, K Dunne, TR Sewell… - Nature …, 2022 - nature.com
Infections caused by the fungal pathogen Aspergillus fumigatus are increasingly resistant to
first-line azole antifungal drugs. However, despite its clinical importance, little is known …

Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America

TF Patterson, GR Thompson III… - Clinical infectious …, 2016 - academic.oup.com
It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Antifungal resistance: current trends and future strategies to combat

NP Wiederhold - Infection and drug resistance, 2017 - Taylor & Francis
Antifungal resistance represents a major clinical challenge to clinicians responsible for
treating invasive fungal infections due to the limited arsenal of systemically available …

Azole-resistant Aspergillus fumigatus in the environment: Identifying key reservoirs and hotspots of antifungal resistance

C Burks, A Darby, L Gómez Londoño… - PLoS …, 2021 - journals.plos.org
Aspergillus fumigatus is an opportunistic human pathogen that causes aspergillosis, a
spectrum of environmentally acquired respiratory illnesses. It has a cosmopolitan distribution …

Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management

DW Denning, J Cadranel… - European …, 2015 - publications.ersnet.org
Chronic pulmonary aspergillosis (CPA) is an uncommon and problematic pulmonary
disease, complicating many other respiratory disorders, thought to affect∼ 240 000 people …

[HTML][HTML] Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline

AJ Ullmann, JM Aguado, S Arikan-Akdagli… - Clinical Microbiology …, 2018 - Elsevier
Abstract The European Society for Clinical Microbiology and Infectious Diseases, the
European Confederation of Medical Mycology and the European Respiratory Society Joint …

The clinical spectrum of pulmonary aspergillosis

C Kosmidis, DW Denning - Thorax, 2015 - thorax.bmj.com
The clinical presentation of Aspergillus lung disease is determined by the interaction
between fungus and host. Invasive aspergillosis develops in severely immunocompromised …

Antifungal therapy: new advances in the understanding and treatment of mycosis

L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …