With or without you—Proteomics with or without major plasma/serum proteins

E Gianazza, I Miller, L Palazzolo, C Parravicini… - Journal of …, 2016 - Elsevier
The first sections of this review compile and discuss strategies and protocols for managing
plasma/serum as a source of biomarkers relevant to human disease. In many such cases …

Moonlighting proteins: beacon of hope in era of drug resistance in bacteria

P Yadav, R Singh, S Sur, S Bansal… - Critical Reviews in …, 2023 - Taylor & Francis
Moonlighting proteins (MLPs) are ubiquitous and provide a unique advantage to bacteria
performing multiple functions using the same genomic content. Targeting MLPs can be …

Role of moonlighting proteins in disease: analyzing the contribution of canonical and moonlighting functions in disease progression

M Huerta, L Franco-Serrano, I Amela, JA Perez-Pons… - Cells, 2023 - mdpi.com
The term moonlighting proteins refers to those proteins that present alternative functions
performed by a single polypeptide chain acquired throughout evolution (called canonical …

Structural Predictive Model of Presenilin‐2 Protein and Analysis of Structural Effects of Familial Alzheimer's Disease Mutations

A Soto-Ospina, P Araque Marín… - Biochemistry …, 2021 - Wiley Online Library
Alzheimer's disease manifests itself in brain tissue by neuronal death, due to aggregation of
β‐amyloid, produced by senile plaques, and hyperphosphorylation of the tau protein, which …

Pathogen moonlighting proteins: from ancestral key metabolic enzymes to virulence factors

L Franco-Serrano, D Sánchez-Redondo… - Microorganisms, 2021 - mdpi.com
Moonlighting and multitasking proteins refer to proteins with two or more functions
performed by a single polypeptide chain. An amazing example of the Gain of Function (GoF) …

Multifunctional proteins: involvement in human diseases and targets of current drugs

L Franco-Serrano, M Huerta, S Hernández… - The Protein …, 2018 - Springer
Multifunctionality or multitasking is the capability of some proteins to execute two or more
biochemical functions. The objective of this work is to explore the relationship between …

Network of surface-displayed glycolytic enzymes in Mycoplasma pneumoniae and their interactions with human plasminogen

A Gründel, M Pfeiffer, E Jacobs, R Dumke - Infection and immunity, 2016 - Am Soc Microbiol
In different bacteria, primarily cytosolic and metabolic proteins are characterized as surface
localized and interacting with different host factors. These moonlighting proteins include …

Bioinformatics and moonlighting proteins

S Hernández, L Franco, A Calvo, G Ferragut… - … in bioengineering and …, 2015 - frontiersin.org
Multitasking or moonlighting is the capability of some proteins to execute two or more
biochemical functions. Usually, moonlighting proteins are experimentally revealed by …

Determinació de les proteïnes multifuncionals de Mycoplasma genitalium

N Paredes Felipe - 2022 - openaccess.uoc.edu
Les proteïnes moonlighting són proteïnes amb més d'una funció. Moltes estan implicades
en malalties humanes i en són dianes de fàrmacs actuals. També s' ha vist que estan …

Proteínas multifuncionales, enfermedades humanas y dianas farmacológicas: una actualización

JF Rojas Cabeza - 2020 - openaccess.uoc.edu
La multifuncionalidad de proteínas se refiere a su habilidad para llevar a cabo un cabo dos
o más funciones biológicas. El objetivo de este trabajo fue examinar con herramientas …