Rationale: Genome-wide association studies previously identified an association of
rs9388451 at chromosome 6q22. 3 (near HEY2) with Brugada syndrome. The causal gene …

Diabetes and other metabolic conditions characterized by elevated blood glucose constitute
important risk factors for cardiovascular disease. Hyperglycemia targets myocardial cells …

The present study investigates the physiological role of Kvβ1 subunit for sensing pyridine
nucleotide (NADH/NAD+) changes in the heart. We used Kvβ1. 1 knockout (KO) or wild-type …

Retigabine is a new antiepileptic drug with the main mechanism of action: activation of
voltage-gated potassium channels (Kv7) represented in many tissues including the excitable …

Aim Cardiovascular complications, including cardiac arrhythmias, result in high morbidity
and mortality in patients with type‐2 diabetes mellitus (T2DM). Clinical and experimental …

ABSTRACT Potassium Channel Interacting Protein 2 (KChIP2) is suggested to be
responsible for the circadian rhythm in repolarization duration, ventricular arrhythmias, and …

Electrophysiologists routinely use simple voltage steps to evaluate cell membrane
capacitance derived from corresponding current responses. Frequently, the resting …

Ionic currents over the plasma membrane through channels are the cornerstone of excitable
cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized …

TO THE EDITOR: Cell membrane capacitance Cm is a fundamental property of excitable
cells. It scales with the cell surface area and is therefore used for cell size estimation and …

The heart-failure relevant Potassium Channel Interacting Protein 2 (KChIP2) augments
CaV1. 2 and KV4. 3. KChIP3 represses CaV1. 2 transcription in cardiomyocytes via …