[HTML][HTML] Deadly excess copper

J Sailer, J Nagel, B Akdogan, AT Jauch, J Engler… - Redox biology, 2024 - Elsevier
Higher eukaryotes' life is impossible without copper redox activity and, literally, every breath
we take biochemically demonstrates this. However, this dependence comes at a …

A comprehensive review on techniques to create the anti-microbial surface of biomaterials to intervene in biofouling

S Kumar, DN Roy, V Dey - Colloid and Interface Science Communications, 2021 - Elsevier
The development of microorganisms' colonies creates a three-dimensional structure named
biofilm, which helps microorganisms attach to the substratum to survive. The …

Mitochondrial electron transport chain in heavy metal‐induced neurotoxicity: Effects of cadmium, mercury, and copper

EA Belyaeva, TV Sokolova… - The Scientific World …, 2012 - Wiley Online Library
To clarify the role of mitochondrial electron transport chain (mtETC) in heavy‐metal‐induced
neurotoxicity, we studied action of Cd2+, Hg2+, and Cu2+ on cell viability, intracellular …

The inhibition of NFкB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity

A Ahmadi, H Niknahad, H Li, A Mobasheri… - Toxicology Letters, 2021 - Elsevier
The cholestatic liver injury could occur in response to a variety of diseases or xenobiotics.
Although cholestasis primarily affects liver function, it has been well-known that other organs …

Copper sulfate-induced endoplasmic reticulum stress promotes hepatic apoptosis by activating CHOP, JNK and caspase-12 signaling pathways

H Wu, H Guo, H Liu, H Cui, J Fang, Z Zuo… - Ecotoxicology and …, 2020 - Elsevier
Copper (Cu), a transition metal, is an essential trace element in human and animal nutrition
at low concentration, but Cu has toxic effects on tissues and organs at high concentration …

Neurotoxicity of copper

F Bulcke, R Dringen, IF Scheiber - Neurotoxicity of metals, 2017 - Springer
Copper is an essential trace metal that is required for several important biological
processes, however, an excess of copper can be toxic to cells. Therefore, systemic and …

Curcumin and nano-curcumin mitigate copper neurotoxicity by modulating oxidative stress, inflammation, and akt/gsk-3β signaling

WS Sarawi, AM Alhusaini, LM Fadda, HA Alomar… - Molecules, 2021 - mdpi.com
Copper (Cu) is essential for multiple biochemical processes, and copper sulphate (CuSO4)
is a pesticide used for repelling pests. Accidental or intentional intoxication can induce …

Concerns in the application of fluorescent probes DCDHF-DA, DHR 123 and DHE to measure reactive oxygen species in vitro

M Yazdani - Toxicology in vitro, 2015 - Elsevier
Reactive oxygen species (ROS) are formed in biological systems by partial reduction of
molecular oxygen. The essential role of ROS in maintaining physiological health may be …

Nano-curcumin prevents cardiac injury, oxidative stress and inflammation, and modulates TLR4/NF-κB and MAPK signaling in copper sulfate-intoxicated rats

WS Sarawi, AM Alhusaini, LM Fadda, HA Alomar… - Antioxidants, 2021 - mdpi.com
Copper (Cu) is essential for a plethora of biological processes; however, its high redox
reactivity renders it potentially toxic. This study investigated the protective effect of curcumin …

Colchicine increases intestinal permeability, suppresses inflammatory responses, and alters gut microbiota in mice

Y Shi, J Li, P Yang, Z Niu, L Wei, L Chen, L Gao - Toxicology Letters, 2020 - Elsevier
Although colchicine (COL) has been used to treat gout for more than a thousand years, it
has been shrouded in a dark history for a long time due to its high toxicity, especially for the …