Malaria in Brazil: an overview
J Oliveira-Ferreira, MVG Lacerda, P Brasil… - Malaria journal, 2010 - Springer
Malaria is still a major public health problem in Brazil, with approximately 306 000 registered
cases in 2009, but it is estimated that in the early 1940s, around six million cases of malaria …
cases in 2009, but it is estimated that in the early 1940s, around six million cases of malaria …
A new challenge for malaria control in Brazil: asymptomatic Plasmodium infection-a review
JR Coura, M Suárez-Mutis… - Memórias do Instituto …, 2006 - SciELO Brasil
The evolution of malaria in Brazil, its morbidity, the malaria control programs, and the new
challenges for these programs in the light of the emergence of asymptomatic infection in the …
challenges for these programs in the light of the emergence of asymptomatic infection in the …
Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya
BR Ogutu, OJ Apollo, D McKinney, W Okoth, J Siangla… - PloS one, 2009 - journals.plos.org
Objective The antigen, falciparum malaria protein 1 (FMP1), represents the 42-kDa C-
terminal fragment of merozoite surface protein-1 (MSP-1) of the 3D7 clone of P. falciparum …
terminal fragment of merozoite surface protein-1 (MSP-1) of the 3D7 clone of P. falciparum …
Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparum Merozoite Antigens Are Associated with Control of Parasitemia and Protection from …
DI Stanisic, JS Richards, FJ McCallum… - Infection and …, 2009 - Am Soc Microbiol
Substantial evidence indicates that antibodies to Plasmodium falciparum merozoite antigens
play a role in protection from malaria, although the precise targets and mechanisms …
play a role in protection from malaria, although the precise targets and mechanisms …
Acquisition of antibodies against Plasmodium falciparum merozoites and malaria immunity in young children and the influence of age, force of infection, and …
Individuals in areas of Plasmodium falciparum endemicity develop immunity to malaria after
repeated exposure. Knowledge of the acquisition and nature of protective immune …
repeated exposure. Knowledge of the acquisition and nature of protective immune …
Clinical protection from falciparum malaria correlates with neutrophil respiratory bursts induced by merozoites opsonized with human serum antibodies
C Joos, L Marrama, HEJ Polson, S Corre, AM Diatta… - PloS one, 2010 - journals.plos.org
Background Effective vaccines to combat malaria are urgently needed, but have proved
elusive in the absence of validated correlates of natural immunity. Repeated blood stage …
elusive in the absence of validated correlates of natural immunity. Repeated blood stage …
Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children
Background Antigen-specific antibody-mediated immune responses play an important role
in natural protection against clinical malaria, but conflicting estimates of this association …
in natural protection against clinical malaria, but conflicting estimates of this association …
Natural acquisition of immunity to Plasmodium vivax: epidemiological observations and potential targets
Population studies show that individuals acquire immunity to Plasmodium vivax more
quickly than Plasmodium falciparum irrespective of overall transmission intensity, resulting …
quickly than Plasmodium falciparum irrespective of overall transmission intensity, resulting …
The Quantity and Quality of African Children's IgG Responses to Merozoite Surface Antigens Reflect Protection against Plasmodium falciparum Malaria
D Courtin, M Oesterholt, H Huismans, K Kusi, J Milet… - PloS one, 2009 - journals.plos.org
Background Antibodies, particularly cytophilic IgG subclasses, with specificity for asexual
blood stage antigens of Plasmodium falciparum, are thought to play an important role in …
blood stage antigens of Plasmodium falciparum, are thought to play an important role in …
A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide® ISA 720
JS McCarthy, J Marjason, S Elliott, P Fahey, G Bang… - PloS one, 2011 - journals.plos.org
Background In a previous Phase 1/2b malaria vaccine trial testing the 3D7 isoform of the
malaria vaccine candidate Merozoite surface protein 2 (MSP2), parasite densities in children …
malaria vaccine candidate Merozoite surface protein 2 (MSP2), parasite densities in children …