Tooth enamel is a complex mineralized tissue consisting of long and parallel apatite crystals
configured into decussating enamel rods. In recent years, multiple approaches have been …

Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …

Organogenesis depends upon a well-ordered series of inductive events involving
coordination of molecular pathways that regulate the generation and patterning of specific …

A subset of ciliopathies, including Sensenbrenner, Jeune, and short-rib polydactyly
syndromes are characterized by skeletal anomalies accompanied by multiorgan defects …

Mice carrying mutations in Wise (Sostdc1) display defects in many aspects of tooth
development, including tooth number, size and cusp pattern. To understand the basis of …

Despite advances in the knowledge of tooth morphogenesis and differentiation, relatively
little is known about the aetiology and molecular mechanisms underlying supernumerary …

Odontoblasts are dentin-secreting cells that survive for the whole life of a healthy tooth. Once
teeth are completely erupted, odontoblasts transform into a mature stage that allows for their …

Tooth number abnormality is one of the most common dental developmental diseases,
which includes both tooth agenesis and supernumerary teeth. Tooth development is …

Four conserved signaling pathways, including the bone morphogenetic proteins (Bmp),
fibroblast growth factors (Fgf), sonic hedgehog (Shh), and wingless-related (Wnt) pathways …

Supernumerary teeth are common clinical dental anomalies. Although various studies have
provided abundant information regarding genes and signaling pathways involved in tooth …