Myriad mechanisms have evolved to adapt to changing environments. Environmental stimuli
alter organisms' physiology to create memories of previous environments. Whether these …

To date, there is no reliable biomarker for the assessment or determination of cognitive
dysfunction in Alzheimer's disease and related dementia. Such a biomarker would not only …

Unchecked inflammation is a hallmark of inflammatory tissue injury in diseases such as
acute respiratory distress syndrome (ARDS). Yet the mechanisms of inflammatory lung injury …

Nervous system maps are of critical importance for understanding how nervous systems
develop and function. We systematically map here all cholinergic neuron types in the male …

The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …

Insulin/insulin-like growth factor signalling (IIS) is a critical regulator of an organism's most
important biological decisions from growth, development, and metabolism to reproduction …

The gut microbiota affects tissue physiology, metabolism, and function of both the immune
and nervous systems. We found that intrinsic enteric-associated neurons (iEANs) in mice are …

Memories formed early in life are particularly stable and influential, representing privileged
experiences that shape enduring behaviors. We show that exposing newly hatched C …

Cyclic-AMP response element-binding protein (CREB) signaling has a critical role in the
formation of memories. CREB signaling is dysfunctional in the brains of mouse models of …

Animals with complex nervous systems demand sleep for memory consolidation and
synaptic remodeling. Here, we show that, although the Caenorhabditis elegans nervous …