Studying viral–host protein–protein interactions can facilitate the discovery of therapies for
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …

Background Ubiquitination is essential for many cellular processes in eukaryotes, including
26S proteasome-dependent protein degradation, cell cycle progression, transcriptional …

Widespread availability of protein sequence-fitness data would revolutionize both our
biochemical understanding of proteins and our ability to engineer them. Unfortunately, even …

Cytokinin is a plant hormone regulating numerous biological processes. Its diverse functions
are realized through the expression control of specific target genes. The transcription of the …

The evolution of new traits in living organisms occurs via the processes of mutation,
recombination, genetic drift, and selection. These processes that have resulted in the …

Prions are often considered as molecular memory devices, generating reproducible memory
of a conformational change. Prion-like proteins (PrLPs) have been widely demonstrated to …

Network science identifies key players in diverse biological systems including host-
pathogen interactions. We demonstrated a scale-free network property for a comprehensive …

Currently, the experimentally identified interactome of Arabidopsis (Arabidopsis thaliana) is
still far from complete, suggesting that computational prediction methods can complement …

The barley MLA nucleotide-binding leucine-rich-repeat (NLR) receptor and its orthologs
confer recognition specificity to many fungal diseases, including powdery mildew, stem-, and …

Comprehensive protein-protein interaction (PPI) maps are critical for understanding the
functional organization of the proteome, but challenging to produce experimentally. Here …