[HTML][HTML] Ubiquitin–proteasome system (UPS) as a target for anticancer treatment
J Park, J Cho, EJ Song - Archives of pharmacal research, 2020 - Springer
The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …
[HTML][HTML] Ubiquitin signaling in cell cycle control and tumorigenesis
Cell cycle progression is a tightly regulated process by which DNA replicates and cell
reproduces. The major driving force underlying cell cycle progression is the sequential …
reproduces. The major driving force underlying cell cycle progression is the sequential …
[HTML][HTML] The opportunities and challenges in immunotherapy: Insights from the regulation of PD-L1 in cancer cells
Q Lin, X Wang, Y Hu - Cancer Letters, 2023 - Elsevier
The immunosuppressive molecule programmed death-ligand 1 (PD-L1) is frequently
upregulated in human cancers. Binding of PD-L1 to its receptor, programmed death-1 (PD …
upregulated in human cancers. Binding of PD-L1 to its receptor, programmed death-1 (PD …
[HTML][HTML] Beyond K48 and K63: non-canonical protein ubiquitination
M Tracz, W Bialek - Cellular & molecular biology letters, 2021 - Springer
Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …
modifications. Originally discovered as a critical element in highly regulated proteolysis …
Biochemical aspects of PD-L1 regulation in cancer immunotherapy
PD-L1, frequently expressed in human cancers, engages with PD-1 on immune cells and
contributes to cancer immune evasion. As such, antibodies blocking the PD-1/PD-L1 …
contributes to cancer immune evasion. As such, antibodies blocking the PD-1/PD-L1 …
Targeting Cdc20 as a novel cancer therapeutic strategy
Abstract The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …
[HTML][HTML] The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells
S Zhang, X You, Y Zheng, Y Shen… - The Journal of …, 2023 - Am Soc Clin Investig
Ubiquitin-conjugating enzyme E2C (UBE2C) mediates ubiquitylation chain formation via the
K11 linkage. While previous in vitro studies showed that UBE2C plays a growth-promoting …
K11 linkage. While previous in vitro studies showed that UBE2C plays a growth-promoting …
Targeting Cdc20 for cancer therapy
Abstract The Anaphase-Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase,
and two co-activators, Cdc20 and Cdh1, enable the ubiquitin-dependent proteasomal …
and two co-activators, Cdc20 and Cdh1, enable the ubiquitin-dependent proteasomal …
[HTML][HTML] Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours
K Litchfield, B Summersgill, S Yost, R Sultana… - Nature …, 2015 - nature.com
Testicular germ cell tumours (TGCTs) are the most common cancer in young men. Here we
perform whole-exome sequencing (WES) of 42 TGCTs to comprehensively study the …
perform whole-exome sequencing (WES) of 42 TGCTs to comprehensively study the …
Posing the APC/C E3 ubiquitin ligase to orchestrate cell division
The anaphase promoting complex/cyclosome (APC/C) E3 ligase controls mitosis and
nonmitotic pathways through interactions with proteins that coordinate ubiquitylation. Since …
nonmitotic pathways through interactions with proteins that coordinate ubiquitylation. Since …