Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
SE Arnold, Z Arvanitakis… - Nature Reviews …, 2018 - nature.com
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …
[HTML][HTML] Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised …
JT Yu, W Xu, CC Tan, S Andrieu, J Suckling… - Journal of Neurology …, 2020 - jnnp.bmj.com
Background Evidence on preventing Alzheimer's disease (AD) is challenging to interpret
due to varying study designs with heterogeneous endpoints and credibility. We completed a …
due to varying study designs with heterogeneous endpoints and credibility. We completed a …
[HTML][HTML] The effects of intermittent fasting on brain and cognitive function
The importance of diet and the gut-brain axis for brain health and cognitive function is
increasingly acknowledged. Dietary interventions are tested for their potential to prevent …
increasingly acknowledged. Dietary interventions are tested for their potential to prevent …
Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia
S Chatterjee, SAE Peters, M Woodward… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE Type 2 diabetes confers a greater excess risk of cardiovascular disease in
women than in men. Diabetes is also a risk factor for dementia, but whether the association …
women than in men. Diabetes is also a risk factor for dementia, but whether the association …
[HTML][HTML] Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: a review and synthesis
As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …
incidence and prevalence of dementia increases, and the need to understand the etiology …
[HTML][HTML] Hesperidin as a neuroprotective agent: a review of animal and clinical evidence
Neuroprotection is the preservation of function and networks of neural tissues from damages
caused by various agents, as well as neurodegenerative diseases such as Parkinson's …
caused by various agents, as well as neurodegenerative diseases such as Parkinson's …
[HTML][HTML] The overlap between vascular disease and Alzheimer's disease-lessons from pathology
J Attems, KA Jellinger - BMC medicine, 2014 - Springer
Recent epidemiological and clinico-pathological data indicate considerable overlap
between cerebrovascular disease (CVD) and Alzheimer's disease (AD) and suggest …
between cerebrovascular disease (CVD) and Alzheimer's disease (AD) and suggest …
Hippocampal insulin resistance and cognitive dysfunction
GJ Biessels, LP Reagan - Nature Reviews Neuroscience, 2015 - nature.com
Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …
Risk factors associated with the onset and progression of Alzheimer's disease: A systematic review of the evidence
M Hersi, B Irvine, P Gupta, J Gomes, N Birkett… - Neurotoxicology, 2017 - Elsevier
A systematic review was conducted to identify risk factors associated with the onset and
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …
[HTML][HTML] The therapeutic potential of metformin in neurodegenerative diseases
C Rotermund, G Machetanz… - Frontiers in endocrinology, 2018 - frontiersin.org
The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …
today's aging population and an increasing burden on individuals, families, and society …