Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

SE Arnold, Z Arvanitakis… - Nature Reviews …, 2018 - nature.com
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

[HTML][HTML] Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised …

JT Yu, W Xu, CC Tan, S Andrieu, J Suckling… - Journal of Neurology …, 2020 - jnnp.bmj.com
Background Evidence on preventing Alzheimer's disease (AD) is challenging to interpret
due to varying study designs with heterogeneous endpoints and credibility. We completed a …

[HTML][HTML] The effects of intermittent fasting on brain and cognitive function

J Gudden, A Arias Vasquez, M Bloemendaal - Nutrients, 2021 - mdpi.com
The importance of diet and the gut-brain axis for brain health and cognitive function is
increasingly acknowledged. Dietary interventions are tested for their potential to prevent …

Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia

S Chatterjee, SAE Peters, M Woodward… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE Type 2 diabetes confers a greater excess risk of cardiovascular disease in
women than in men. Diabetes is also a risk factor for dementia, but whether the association …

[HTML][HTML] Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: a review and synthesis

CY Santos, PJ Snyder, WC Wu, M Zhang… - Alzheimer's & Dementia …, 2017 - Elsevier
As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

[HTML][HTML] Hesperidin as a neuroprotective agent: a review of animal and clinical evidence

M Hajialyani, M Hosein Farzaei, J Echeverría… - Molecules, 2019 - mdpi.com
Neuroprotection is the preservation of function and networks of neural tissues from damages
caused by various agents, as well as neurodegenerative diseases such as Parkinson's …

[HTML][HTML] The overlap between vascular disease and Alzheimer's disease-lessons from pathology

J Attems, KA Jellinger - BMC medicine, 2014 - Springer
Recent epidemiological and clinico-pathological data indicate considerable overlap
between cerebrovascular disease (CVD) and Alzheimer's disease (AD) and suggest …

Hippocampal insulin resistance and cognitive dysfunction

GJ Biessels, LP Reagan - Nature Reviews Neuroscience, 2015 - nature.com
Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …

Risk factors associated with the onset and progression of Alzheimer's disease: A systematic review of the evidence

M Hersi, B Irvine, P Gupta, J Gomes, N Birkett… - Neurotoxicology, 2017 - Elsevier
A systematic review was conducted to identify risk factors associated with the onset and
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …

[HTML][HTML] The therapeutic potential of metformin in neurodegenerative diseases

C Rotermund, G Machetanz… - Frontiers in endocrinology, 2018 - frontiersin.org
The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …