Repeated drug use can change dopamine (DA) function in ways that promote the
development and persistence of addiction, but in what direction? By one view, drug use …

Introduction Comorbidity of substance use disorder (SUD) with schizophrenia, referred to as
dual disorder (DD), significantly increases morbidity and mortality compared to …

Most prior work with positron emission tomography (PET) dopamine subtype 2/3 receptor (D
2/3 R) non-selective antagonist tracers suggests that obese (OB) individuals exhibit lower D …

Research has documented risk for and evidence of behavioral and substance addiction
through neurocircuitry, biochemistry, and genetics. This paper will highlight and complete an …

The dopaminergic system plays a central and decisive role in substance use disorder
(SUD), bipolar disorder (BD), and possibly in a subgroup of patients with refractory …

Introduction Comorbidity of bipolar disorder (BD) and alcohol use disorder (AUD) is very
frequent resulting in detrimental outcomes, including increased mortality. Diagnosis of AUD …

Open access post-mortem transcriptome atlases such as the Allen Human Brain Atlas
(AHBA) can inform us about mRNA expression of numerous proteins of interest across the …

The stochastic framework of the NERA model (N: Nonuser, E: Experimental user, R:
Recreational user, A: Addict) depicting the dynamics of marijuana usage in the pre-and post …

Neuroimaging studies in stimulant use (eg, cocaine, methamphetamine) disorders show that
diminished dopamine release by dopamine-elevating drugs is a potential marker of relapse …

The concept of the high‐affinity state postulates that a certain subset of G‐protein‐coupled
receptors is primarily responsible for receptor signaling in the living brain. Assessing the …