Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

Mammalian photoreceptor outer segment renewal is a highly coordinated process that
hinges on timed cell signaling between photoreceptor neurons and the adjacent retinal …

Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short
palindromic repeats) gene editing system often require viral vectors, which pose safety …

Long non-coding RNAs (lncRNAs) are untranslated transcripts which regulate many
biological processes. Changes in lncRNA expression pattern are well-known related to …

Introduction The vertebrate retinal pigment epithelium (RPE) lies adjacent to the
photoreceptors and is responsible for the engulfment and degradation of shed …

Retinal photoreceptors undergo daily renewal of their distal outer segments, a process
indispensable for maintaining retinal health. Photoreceptor Outer Segment (POS) …

Background Retinal pigment epithelium (RPE) cell therapy is a promising way to treat many
retinal diseases. However, obtaining transplantable RPE cells is time-consuming and less …

Aging may significantly modify antioxidant and photoprotective properties of melanin in
retinal pigment epithelium (RPE). Here, photoreactivity of melanosomes (MS), isolated from …

Primary cilia are sensory organelles vital for developmental and physiological processes.
Their dysfunction causes a range of phenotypes including retinopathies. Although primary …

Diurnal clearance phagocytosis by the retinal pigment epithelium (RPE) is a conserved
efferocytosis process whose binding step is mediated by αvβ5 integrin receptors. Two …