Phosphodiesterase inhibitors for Alzheimer's disease: a systematic review of clinical trials and epidemiology with a mechanistic rationale
O Sanders, L Rajagopal - Journal of Alzheimer's Disease …, 2020 - content.iospress.com
Background: Preclinical studies, clinical trials, and reviews suggest increasing 3', 5'-cyclic
adenosine monophosphate (cAMP) and 3', 5'-cyclic guanosine monophosphate (cGMP) with …
adenosine monophosphate (cAMP) and 3', 5'-cyclic guanosine monophosphate (cGMP) with …
Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies
E Pajarillo, I Nyarko-Danquah, A Digman… - Frontiers in …, 2022 - frontiersin.org
Chronic exposure to elevated levels of manganese via occupational or environmental
settings causes a neurological disorder known as manganism, resembling the symptoms of …
settings causes a neurological disorder known as manganism, resembling the symptoms of …
[HTML][HTML] Evaluating the neuroprotective activities of vinpocetine, punicalagin, niacin and vitamin E against behavioural and motor disabilities of manganese-induced …
K Abu-Elfotuh, AME Hamdan, AN Abbas… - Biomedicine & …, 2022 - Elsevier
Highlights•MnCl 2 induces biochemical changes in the brain: reduction of monoamines and
disturbing the imbalance between excitatory and inhibitory neurotransmitters.•MnCl 2 …
disturbing the imbalance between excitatory and inhibitory neurotransmitters.•MnCl 2 …
Biochemical and behavior effects induced by diheptyl phthalate (DHpP) and Diisodecyl phthalate (DIDP) exposed to zebrafish
Abstract Both Diheptyl-phthalate (DHpP) and Diisodecyl-phthalate (DIDP) were used
extensively as plasticizers. Recently, their occurrence in the environmental matrices and …
extensively as plasticizers. Recently, their occurrence in the environmental matrices and …
Punicalagin's protective effects on Parkinson's progression in socially isolated and socialized rats: insights into multifaceted pathway
Parkinson's disease (PD) is a gradual deterioration of dopaminergic neurons, leading to
motor impairments. Social isolation (SI), a recognized stressor, has recently gained attention …
motor impairments. Social isolation (SI), a recognized stressor, has recently gained attention …
Reactive astrocytes targeting with oral vitamin A: Efficient neuronal regeneration for Parkinson's disease treatment and reversal of associated liver fibrosis
NS El‐Mezayen, MAM Attia, MY Shafik… - CNS Neuroscience …, 2023 - Wiley Online Library
Introduction A recent approach to cure neurodegenerative diseases is to reprogram
fibroblasts into functioning neurons using multiple exogenous transcription factors (TFs) and …
fibroblasts into functioning neurons using multiple exogenous transcription factors (TFs) and …
[HTML][HTML] The protective effect of taurine, piracetam and vinpocetine on etoposide-induced inflammation and brain injury in the serum of female albino rats
AS Mohammed, AN Al-Hassani, RA Alrawi… - …, 2023 - ncbi.nlm.nih.gov
Etoposide (ETP) is one of the leading antitumour agents in cancer chemotherapy. Many
studies have reported on ETP-induced peripheral neuropathy; however, few reports have …
studies have reported on ETP-induced peripheral neuropathy; however, few reports have …
Anti‐apoptotic effect of vinpocetine on cisplatin‐induced hepatotoxicity in mice: The role of Annexin‐V, Caspase‐3, and Bax
SA Habib, RS Abdelrahman… - … of biochemical and …, 2020 - Wiley Online Library
Hepatic damage is one of the most common complications related to cisplatin (Cis) use.
Recently, liver protection lines are being discovered to avoid hepatic cell death as a result of …
Recently, liver protection lines are being discovered to avoid hepatic cell death as a result of …
[HTML][HTML] Vinpocetine's immunomodulating, anti-oxidant, anti-inflammatory, ant-ifibrotic, and PDE inhibiting potencies ameliorate bleomycin-induced pulmonary fibrosis
Results: Vinpocetine dose-dependently ameliorates PF induced by bleomycin
administration since vinpocetine effectively restored the normal body weight gain rates …
administration since vinpocetine effectively restored the normal body weight gain rates …
Manganese increases Aβ and Tau protein levels through proteasome 20S and heat shock proteins 90 and 70 alteration, leading to SN56 cholinergic cell death …
P Moyano, JM García, J García, MJ Anadon… - Ecotoxicology and …, 2020 - Elsevier
Manganese (Mn) produces cholinergic neuronal loss in basal forebrain (BF) region that was
related to cognitive dysfunction induced after single and repeated Mn treatment. All …
related to cognitive dysfunction induced after single and repeated Mn treatment. All …