The development of cutting-edge techniques to study specific brain regions and neural
circuits that regulate sleep–wake brain states and general anesthesia (GA), has increased …

Acute myocardial infarction (AMI) and the heart failure (HF) that often complicates this
condition, are among the leading causes of death and disability worldwide. To reduce …

Background: The present clinical trial investigated the potential influences of dosage and
age on the pharmacokinetic properties and safety profile of HSK3486, and whether any …

The midbrain periaqueductal gray (PAG) organizes basic survival behavior, which includes
respiration. How the PAG controls respiration is not known. We studied the PAG control of …

The GABA A receptor has been identified as the single most important target for the
intravenous anesthetic propofol. How effects at this receptor are then translated into a loss of …

Background Propofol is an intravenous anesthetic associated with hypotension, respiratory
depression, and injection-site pain. HSK3486 injectable emulsion (ciprofol) is a 2, 6 …

Cranial visceral afferents enter the brain at the solitary tract nucleus (NTS). GABAergic
neurons are scattered throughout the NTS, but their relation to solitary tract (ST) afferent …

Signalling pathways underlying the phenomenon of remote ischaemic preconditioning
(RPc) cardioprotection are not completely understood. The existing evidence agrees that …

Study objectives We conducted a non-inferiority study to assess the postoperative quality of
recovery (QoR) in elderly patients receiving ciprofol or propofol total intravenous anesthersia …

Rhythmic eupneic breathing in mammals depends on the coordinated activities of the neural
system that sends cranial and spinal motor outputs to respiratory muscles. These outputs …