It has been 50 years since Francis Fontan pioneered the operation that today bears his
name. Initially designed for patients with tricuspid atresia, this procedure is now offered for a …

The harmful use of alcohol has been estimated to cause approximately 3.3 million deaths
every year, corresponding to nearly 6% of all deaths globally. Therefore, the effective …

The extracellular matrix (ECM) is dynamically tuned to optimize physiological function. Its
major properties, including composition and mechanics, profoundly influence cell biology …

Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Hepatocellular carcinoma (HCC), as the fifth most common malignant cancer, develops and
progresses mostly in a cirrhotic liver where stiff nodules are separated by fibrous bands …

Decellularized extracellular matrices (dECMs) have demonstrated excellent utility as
bioscaffolds in recapitulating the complex biochemical microenvironment, however, their use …

Vibration‐controlled transient elastography estimates liver stiffness measurement (LSM) and
controlled attenuation parameter (CAP), which are noninvasive assessments of hepatic …

Alcoholic liver disease (ALD) is the most prevalent cause of advanced liver disease in
Europe. However, there has been limited research investment into ALD despite its …

The recent demonstration that primary cells from the liver can be expanded in vitro as
organoids holds enormous promise for regenerative medicine and disease modelling. The …