The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular
metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low …

Hypoxia is a common phenomenon in solid tumors and is strongly linked to hallmarks of
cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type …

Antibody-dependent enhancement (ADE) is a phenomenon in which preexisting poorly
neutralizing antibodies leads to enhanced infection. It is a serious concern with mosquito …

Liver disease is a growing global health problem, as deaths from end-stage liver cirrhosis
and cancer are rising across the world. At present, pharmacologic approaches to effectively …

As blood flows from the portal triad to the central vein, cell-mediated depletion establishes
gradients of soluble factors such as oxygen, nutrients, and hormones, which act through …

Importance The influence of sleep-disordered breathing (SDB) and sleep-related hypoxemia
in SARS-CoV-2 viral infection and COVID-19 outcomes remains unknown. Controversy …

L-Dopa decarboxylase (DDC) is the most significantly co-expressed gene with ACE2, which
encodes for the SARS-CoV-2 receptor a ngiotensin-c onverting e nzyme 2 and the interferon …

Coronavirus disease 2019 (COVID-19) infection has been linked to a broad range of organ
involvement including lungs, heart and blood vessels, and gastrointestinal tract. 1 The most …

Olive oil phenols (OOPs) are associated with the prevention of many human cancers. Some
of these have been shown to inhibit cell proliferation and induce apoptosis. However, no …