Immune activation is essential for the antitumor activity of EZH2 inhibition in urothelial carcinoma

A Piunti, K Meghani, Y Yu, AG Robertson… - Science …, 2022 - science.org
The long-term survival of patients with advanced urothelial carcinoma (UCa) is limited
because of innate resistance to treatment. We identified elevated expression of the histone …

Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance

HA Abdel-Hafiz, SKK Mani, W Huang, KH Gouin… - Iscience, 2023 - cell.com
Bladder cancer (BLCA) is more common in men but more aggressive in women. Sex-based
differences in cancer biology are commonly studied using a murine model with BLCA …

Non-Invasive Imaging Modalities in Intravesical Murine Models of Bladder Cancer

S Relouw, GJ Dugbartey, A Sener - Cancers, 2023 - mdpi.com
Simple Summary Bladder cancer (BCa) requires the investigation of alternative therapies.
Prior to clinical testing, researchers require the use of animal models to thoroughly …

[HTML][HTML] Pharmacological Inhibition of Endogenous Hydrogen Sulfide Production Slows Bladder Cancer Progression in an Intravesical Murine Model

S Relouw, GJ Dugbartey, P McLeod, NN Knier… - Pharmaceuticals, 2024 - mdpi.com
Present bladder cancer therapies have relatively limited therapeutic impact and account for
one of the highest lifetime treatment costs per patient. Therefore, there is an urgent need to …

BBN-driven urinary bladder cancer mouse model

J Korac-Prlic, M Degoricija, K Vilović, S Vujević… - Methods in cell …, 2021 - Elsevier
Around 3% of new cancer diagnoses and 2% of all cancer deaths every year are caused by
urinary bladder cancer (BC). This indicates a great need for intensive studying of BC by …

[PDF][PDF] Spontaneous and Chemically-induced Bladder Cancer Animal Model

Z Yang, Z Shen, N Zhang, S Bai, L Wang, F Naz… - Cancer, 2020 - academia.edu
Investigations using animal model systems have been enlightening us with the biology
underpinning the development of bladder cancer besides strengthening the existing therapy …

[引用][C] Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance

S Hafiz, K Kailasam, W Mani, SRV Knott… - europepmc.org
Bladder cancer (BLCA) is more common in men but more aggressive in women. Sex-based
differences in cancer biology are commonly studied using a murine model with BLCA …