Multiple-system atrophy

A Fanciulli, GK Wenning - New England Journal of Medicine, 2015 - Mass Medical Soc
Multiple-system atrophy is a neurodegenerative disease characterized by progressive
autonomic failure, parkinsonism, and cerebellar and pyramidal tract symptoms. Glial …

Alpha-synuclein biology in Lewy body diseases

WS Kim, K Kågedal, GM Halliday - Alzheimer's research & therapy, 2014 - Springer
Abstract α-Synuclein is an abundantly expressed neuronal protein that is at the center of
focus in understanding a group of neurodegenerative disorders called α-synucleinopathies …

Multiple system atrophy: pathology, pathogenesis, and path forward

A Ndayisaba, GM Halliday… - Annual Review of …, 2024 - annualreviews.org
Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by
autonomic failure and motor impairment. The hallmark pathologic finding in MSA is …

Multiple system atrophy: an oligodendroglioneural synucleinopathy

KA Jellinger - Journal of Alzheimer's Disease, 2018 - content.iospress.com
Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential

N Ferreira, H Gram, ZA Sorrentino, E Gregersen… - Acta …, 2021 - Springer
Pathology consisting of intracellular aggregates of alpha-Synuclein (α-Syn) spread through
the nervous system in a variety of neurodegenerative disorders including Parkinson's …

Multiple system atrophy: an update

N Stefanova, P Bücke, S Duerr, GK Wenning - The Lancet Neurology, 2009 - thelancet.com
Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative
disorder that presents with autonomic failure in combination with parkinsonism or cerebellar …

The neuropathology, pathophysiology and genetics of multiple system atrophy

Z Ahmed, YT Asi, A Sailer, AJ Lees… - Neuropathology and …, 2012 - Wiley Online Library
Z. Ahmed, YT Asi, A. Sailer, AJ Lees, H. Houlden, T. Revesz and JL Holton (2012)
Neuropathology and Applied Neurobiology38, 4–24 The neuropathology, pathophysiology …

Multiple system atrophy: insights into a rare and debilitating movement disorder

F Krismer, GK Wenning - Nature Reviews Neurology, 2017 - nature.com
Multiple system atrophy (MSA) is a devastating and fatal neurodegenerative disorder. The
clinical presentation of this disease is highly variable, with parkinsonism, cerebellar ataxia …

[HTML][HTML] Glia and alpha-synuclein in neurodegeneration: A complex interaction

D Brück, GK Wenning, N Stefanova, L Fellner - Neurobiology of disease, 2016 - Elsevier
Abstract α-Synucleinopathies (ASP) comprise adult-onset, progressive neurodegenerative
disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple …

Multiple system atrophy: at the crossroads of cellular, molecular and genetic mechanisms

N Stefanova, GK Wenning - Nature Reviews Neuroscience, 2023 - nature.com
Multiple system atrophy (MSA) is a rare oligodendroglial α-synucleinopathy characterized by
neurodegeneration in striatonigral and olivopontocerebellar regions and autonomic brain …