In vitro innovation of tendon tissue engineering strategies

MR Citeroni, MC Ciardulli, V Russo… - International journal of …, 2020 - mdpi.com
Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon
healing results in scar tissue formation and fibrosis with suboptimal biomechanical …

Exploring polysaccharide and protein-enriched decellularized matrix scaffolds for tendon and ligament repair: a review

S Anjum, T Li, M Saeed, Q Ao - International Journal of Biological …, 2023 - Elsevier
Tissue engineering (TE) has become a primary research topic for the treatment of diseased
or damaged tendon/ligament (T/L) tissue. T/L injuries pose a severe clinical burden …

A biomimetic adhesive and robust janus patch with anti-oxidative, anti-inflammatory, and anti-bacterial activities for tendon repair

Q Zhang, Y Yang, D Suo, S Zhao, JCW Cheung… - ACS …, 2023 - ACS Publications
Early stage oxidative stress, inflammatory response, and infection after tendon surgery are
highly associated with the subsequent peritendinous adhesion formation, which may …

Magneto-mechanical actuation of magnetic responsive fibrous scaffolds boosts tenogenesis of human adipose stem cells

AR Tomás, AI Gonçalves, E Paz, P Freitas… - Nanoscale, 2019 - pubs.rsc.org
Tendons are highly specialized load-bearing tissues with very limited healing capacity.
Given their mechanosensitive nature, the combination of tendon mimetic scaffolds with …

Mechanical and biochemical stimulation of 3D multilayered scaffolds for tendon tissue engineering

C Rinoldi, A Fallahi, IK Yazdi… - ACS biomaterials …, 2019 - ACS Publications
Tendon injuries are frequent and occur in the elderly, young, and athletic populations. The
inadequate number of donors combined with many challenges associated with autografts …

Tendon immune regeneration: insights on the synergetic role of stem and immune cells during tendon regeneration

V Russo, M El Khatib, G Prencipe, MR Citeroni… - Cells, 2022 - mdpi.com
Tendon disorders represent a very common pathology in today's population, and
tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people …

3D-printed hydrogel particles containing PRP laden with TDSCs promote tendon repair in a rat model of tendinopathy

C Li, J Wang, W Yang, K Yu, J Hong, X Ji… - Journal of …, 2023 - Springer
Long-term chronic inflammation after Achilles tendon injury is critical for tendinopathy.
Platelet-rich plasma (PRP) injection, which is a common method for treating tendinopathy …

In vitro loading models for tendon mechanobiology

T Wang, P Chen, M Zheng, A Wang… - Journal of …, 2018 - Wiley Online Library
Tendons are the connective tissue responsible for transferring force from muscles to bones.
A key factor in tendon development, maturation, repair, and degradation is its biomechanical …

Species variations in tenocytes' response to inflammation require careful selection of animal models for tendon research

GL Oreff, M Fenu, C Vogl, I Ribitsch, F Jenner - Scientific Reports, 2021 - nature.com
For research on tendon injury, many different animal models are utilized; however, the
extent to which these species simulate the clinical condition and disease pathophysiology …

Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies

SL Tsai, MT Nödl, JL Galloway - Developmental Dynamics, 2021 - Wiley Online Library
Tendons are specialized matrix‐rich connective tissues that transmit forces from muscle to
bone and are essential for movement. As tissues that frequently transfer large mechanical …