The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

The suprachiasmatic nucleus (SCN) of the hypothalamus orchestrates daily rhythms of
physiology and behavior in mammals. Its circadian (∼ 24 hr) oscillations of gene expression …

Little is known about the ability of Drosophila circadian neurons to promote sleep. Here we
show, using optogenetic manipulation and video recording, that a subset of dorsal clock …

The circadian clock drives periodic oscillations at different levels of an organism from genes
to behavior. This timing system is highly conserved across species from insects to mammals …

Locomotor activity rhythms are controlled by a network of~ 150 circadian neurons within the
adult Drosophila brain. They are subdivided based on their anatomical locations and …

Neuronal plasticity helps animals learn from their environment. However, it is challenging to
link specific changes in defined neurons to altered behavior. Here, we focus on circadian …

Twenty-four hour rhythms in behavior are organized by a network of circadian pacemaker
neurons. Rhythmic activity in this network is generated by intrinsic rhythms in clock neuron …

The brain clock that drives circadian rhythms of locomotor activity relies on a multi-oscillator
neuronal network. In addition to synchronizing the clock with day-night cycles, light also …

The fruit fly Drosophila melanogaster possesses approximately 150 brain clock neurons that
control circadian behavioral rhythms. Even though individual clock neurons have self …

Animal circadian rhythms persist in constant darkness and are driven by intracellular
transcription-translation feedback loops. Although these cellular oscillators communicate …