Lactate, traditionally regarded as a metabolic waste product at the terminal of the glycolysis
process, has recently been found to have multifaceted functional roles in metabolism and …

Increasing evidence indicates that chronic, low-grade inflammation is a significant
contributor to the fundamental pathogenesis of type 2 diabetes mellitus (T2DM) …

Skeletal muscle regeneration is a complex process orchestrated by multiple interacting
steps. An increasing number of reports indicate that inflammatory responses play a central …

Ulcerative colitis (UC) is a chronic idiopathic inflammatory disease affecting the
gastrointestinal tract. Although paeonol has been used for treating UC due to its anti …

Amyotrophic lateral sclerosis (ALS) is a complex neuromuscular disease characterized by
progressive motor neuron degeneration, neuromuscular junction dismantling, and muscle …

HPGD encodes 15-Hydroxyprostaglandin dehydrogenase catalyzing the decomposition of
prostaglandin E2 and has not been reported in multiple sclerosis (MS). We previously found …

Nur77 belongs to the NR4A subfamily of orphan nuclear hormone receptors. It has been
shown to play important roles in metabolism, cancer progression, cellular differentiation, and …

Following skeletal muscle injury, the regeneration begins with local inflammation, which is
accompanied by the removal of dead cells. Phagocytosis of dead cells regulates the …