Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …

The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Several metabolic alterations accumulate over time along with a reduction in biological
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …

Autophagy is a conserved catabolic process that degrades cytoplasmic constituents and
organelles in the lysosome. Starvation-induced protein degradation is a salient feature of …

Obesity poses a severe threat to human health, including the increased prevalence of
hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and …

Autophagy is an evolutionarily conserved lysosome-or vacuole-dependent catabolic
pathway in eukaryotes. Autophagy functions basally for cellular quality control and is …

The innate immune system includes several classes of pattern recognition receptors (PRRs),
including membrane-bound Toll-like receptors (TLRs) and nucleotide-binding …

Autophagy is a catabolic recycling pathway triggered by various intra-or extracellular stimuli
that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents …