Resiniferatoxin (RTX) is an ultrapotent capsaicin analog with a unique spectrum of
pharmacological actions. The therapeutic window of RTX is broad, allowing for the full …

Neuropathic pain, a common symptom of several disorders, exerts a substantial
socioeconomic burden worldwide. Transient receptor potential vanilloid 1 (TRPV1), a non …

Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a Ca2+
permeable, non-selective cation channel that is found primarily in sensory nerve fibres …

The heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of
dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face …

Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …

TRPV1 channels are polymodal cation channels located predominantly on primary afferent
neurons that are activated by inflammatory mediators, capsaicin (the active component in …

Lysophosphatidic acid (LPA) is a bioactive phospholipid that plays a crucial role in
cardiovascular diseases. Here, we question whether LPA contributes to myocardial …

Despite major advancements in our understanding of its fundamental causes, pain—both
acute and chronic—remains a serious health concern. Various preclinical investigations …

Facial infiltrating lipomatosis (FIL) is a congenital disorder. The pathogenesis of FIL is
associated with PIK3CA mutations, but the underlying mechanisms remain undetermined …

Mitochondria are the cornerstones of cellular and body thermogenesis, with an inner
temperature possibly reaching 50 degrees. Here, we report the identification of a human …