An update on vitamin D metabolism

F Saponaro, A Saba, R Zucchi - International journal of molecular …, 2020 - mdpi.com
Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone
homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been …

Endoplasmic reticulum–associated protein degradation

L Krshnan, ML van de Weijer… - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …

[HTML][HTML] Biofortified tomatoes provide a new route to vitamin D sufficiency

J Li, A Scarano, NM Gonzalez, F D'Orso, Y Yue… - Nature Plants, 2022 - nature.com
Poor vitamin D status is a global health problem; insufficiency underpins higher risk of
cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D …

New aspects of vitamin D metabolism and action—Addressing the skin as source and target

D Bikle, S Christakos - Nature Reviews Endocrinology, 2020 - nature.com
Vitamin D has a key role in stimulating calcium absorption from the gut and promoting
skeletal health, as well as many other important physiological functions. Vitamin D is …

Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis

JC Christianson, P Carvalho - The EMBO journal, 2022 - embopress.org
The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER
protein homeostasis is essential for the coordination of its diverse functions and depends on …

Consensus statement on Vitamin D status assessment and supplementation: whys, whens, and hows

A Giustina, JP Bilezikian, RA Adler, G Banfi… - Endocrine …, 2024 - academic.oup.com
Abstract The 6th International Conference,“Controversies in Vitamin D,” was convened to
discuss controversial topics, such as vitamin D metabolism, assessment, actions, and …

[HTML][HTML] Vitamin D: production, metabolism and mechanisms of action

DD Bikle - 2015 - europepmc.org
Vitamin D production in the skin under the influence of sunlight (UVB) is maximized at levels
of sunlight exposure that do not burn the skin. Further metabolism of vitamin D to its major …

Vitamin D: Newer concepts of its metabolism and function at the basic and clinical level

DD Bikle - Journal of the Endocrine Society, 2020 - academic.oup.com
The interest in vitamin D continues unabated with thousands of publications contributing to a
vast and growing literature each year. It is widely recognized that the vitamin D receptor …

Competition between enzymatic and non-enzymatic electrochemical determination of cholesterol

MA Hefnawy, SA Fadlallah, RM El-Sherif… - Journal of …, 2023 - Elsevier
Cholesterol is considered an essential component in animal bodies that plays a vital role in
hormone production and creating vitamin D. The elevated blood cholesterol level increases …

Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19

M Cutolo, V Smith, S Paolino, E Gotelli - Nature Reviews Rheumatology, 2023 - nature.com
Evidence supporting the extra-skeletal role of vitamin D in modulating immune responses is
centred on the effects of its final metabolite, 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3, also …