The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis
elegans, and its biological functions show a high level of evolutionary conservation from the …

MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary
messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and …

Defects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases;
however, targeting RBPs with conventional drugs has proven difficult. PROTACs are a new …

MicroRNAs (miRNAs) can play important gene regulatory roles in nematodes, insects, and
plants by basepairing to mRNAs to specify posttranscriptional repression of these …

In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …

The recent discoveries of microRNAs (miRNAs) and characterization of the first few targets
of their gene products in Caenorhabditis elegans and Drosophila melanogaster have set the …

MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the
message or inhibit translation. The specific function of most mammalian miRNAs is …

MicroRNAs (miRNAs) are an abundant class of∼ 22-nucleotide regulatory RNAs found in
plants and animals. Some miRNAs of plants, Caenorhabditis elegans, and Drosophila play …

Chromatin remodeling proteins are frequently dysregulated in human cancer, yet little is
known about how they control tumorigenesis. Here, we uncover an epigenetic program …

MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization
of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in …