Background: A decrease in serum paraoxonase (PON-1) and arylesterase (ARE) activity has
been reported in rheumatoid arthritis (RA) patients and linked to chronic inflammation and …

Pulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases,
which are characterized by increased alveolar wall thickness, excessive scarring, and …

Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and
vascular abnormalities of the affected organs. Although the etiopathology of this disease is …

Systemic sclerosis (SSc) is a chronic connective tissue disorder characterized by immune
dysregulation, chronic inflammation, vascular endothelial cell dysfunction, and progressive …

Despite being some of the most anecdotally well‐known roads to pathogenesis, the
mechanisms governing autoimmune rheumatic diseases are not yet fully understood. The …

The oxidative-stress-elicited deterioration of chondrocyte function is the initial stage of
changes leading to the disruption of cartilage homeostasis. These changes entail a series of …

Background: Rheumatoid arthritis (RA) is a long-term autoimmune condition marked by
persistent inflammation of the joints and various systemic complications, including …

In systemic sclerosis (SSc, or scleroderma), defective angiogenesis, clinically manifesting
with abnormal capillary architecture and severe capillary reduction, represents a hallmark of …

Systemic vasodilating agents like nitroglycerin (NG) or iloprost (Ilo) show beneficial effects
on intestinal microcirculation during sepsis, which could be attenuated by activation of the …

Methods Twenty-one SSc patients and 20 HC were enrolled. In SSc patients, peripheral
venous blood samples were collected at the first day before the autumn Iloprost infusion (t0) …