Primary lymphedema is a long-term (chronic) condition characterized by tissue lymph
retention and swelling that can affect any part of the body, although it usually develops in the …

Hypotrichosis–lymphedema–telangiectasia syndrome (HLTS) is a rare disorder caused by
autosomal recessive and autosomal dominant mutations in SOX18. This gene encodes a …

Although there is much evidence showing functional relationship between Hedgehog
pathway, in particular Sonic hedgehog, and SOX transcription factors during embryonic …

The molecular pathogenesis of the development of non-small cell lung carcinomas
(NSCLCs) is extremely complex. Understanding the molecular basis of the development of …

Few genetically dominant mutations involved in human disease have been fully explained at
the molecular level. In cases where the mutant gene encodes a transcription factor, the …

The SOX18 gene encodes a transcription factor that plays a notable role in certain
developmental contexts such as lymphangiogenesis, hair follicle development and …

Abstract Aims SRY-box 18 (SOX18) is a transcription factor known for its role in regulating
cell differentiation and lymphatic and blood vessel development. It has been reported that …

The transcription factor SOX18 has been shown to play a role in the development of hair,
blood and lymphatic vessels. Mutations in SOX18 result in hereditary lymphedema, with the …

Genetic and molecular heterogeneity, together with intrinsic and acquired resistance to
therapy, represent the major obstacles to the successful treatment of different types of breast …

Kaposi sarcoma (KS) is a cancer characterized by spindle cells thought to originate from
endothelial cells. The most aggressive form is AIDS-related KS, which is one of the most …