Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

Evolutionary game theory mathematically conceptualizes and analyzes biological
interactions where one's fitness not only depends on one's own traits, but also on the traits of …

The rates and patterns of somatic mutation in normal tissues are largely unknown outside of
humans,,,,,–. Comparative analyses can shed light on the diversity of mutagenesis across …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Cancer progression is an evolutionary process. During this process, evolving cancer cell
populations encounter restrictive ecological niches within the body, such as the primary …

Background Cancer is a common diagnosis in many mammalian species, yet they vary in
their vulnerability to cancer. The factors driving this variation are unknown, but life history …

The Multi-Stage Model of Carcinogenesis (MMC), developed in the 1950 s-70s, postulated
carcinogenesis as a Darwinian somatic selection process. The cellular organization of …

Cetaceans are the longest-living species of mammals and the largest in the history of the
planet. They have developed mechanisms against diseases such cancer, although the …

The p53 tumor suppressor is a transcription factor with roles in cell development, apoptosis,
oncogenesis, aging, and homeostasis in response to stresses and infections. p53 is tightly …

Abstract Sir Richard Peto is well known for proposing puzzling paradoxes in cancer biology—
some more well-known than others. In a 1984 piece, Peto proposed that after decades of …