Room temperature synthesis of bioactive 1, 2, 4-oxadiazoles

SV Baykov, AA Shetnev, AV Semenov… - International Journal of …, 2023 - mdpi.com
1, 2, 4-Oxadiazole is an essential motif in drug discovery represented in many experimental,
investigational, and marketed drugs. This review covers synthetic methods that allow the …

Design, Spectral analysis, DFT calculations, antimicrobial, anti-TB, antioxidant activity and molecular docking studies of novel bis-benzoxazines with cytochrome c …

GY Nagesh, M Javeed, JN Basha, K Prashantha… - Journal of Molecular …, 2022 - Elsevier
We herein report the efficient synthesis of symmetrical bis-benzoxazines by substituted
salicylaldehydes and alkyl diamines. The substituted salicylaldehydes (1a-d) and alkyl …

Synthesis of Quinoline‐Morpholine‐Coupled 1,2,3‐Triazole Hybrids as In vitro EGFR inhibitors

A Mamidala, K Bokkala, NS Thirukovela… - …, 2022 - Wiley Online Library
Herein we described the synthesis of some new quinoline‐morpholine coupled 1, 2, 3‐
triazole hybrids (6 a–n) from 5‐chloroquinolin‐8‐ol using well known reactions like Mannich …

Design and Synthesis of Novel Antioxidant 2-Substituted-5, 7, 8-Trimethyl-1, 4-Benzoxazine Hybrids: Effects on Young and Senescent Fibroblasts

T Fotopoulou, A Papadopoulou, A Tzani, M Mamais… - Antioxidants, 2024 - mdpi.com
The exponential growth of the aged population worldwide is followed by an increase in the
prevalence of age-related disorders. Oxidative stress plays central role in damage …

Synthesis and In Silico Analysis of New Polyheterocyclic Molecules Derived from [1, 4]-Benzoxazin-3-one and Their Inhibitory Effect against Pancreatic α-Amylase and …

M Ellouz, A Ihammi, A Baraich, A Farihi, D Addichi… - Molecules, 2024 - mdpi.com
This study focuses on synthesizing a new series of isoxazolinyl-1, 2, 3-triazolyl-[1, 4]-
benzoxazin-3-one derivatives 5a–5o. The synthesis method involves a double 1, 3-dipolar …

Design, Synthesis, and Bioactivity of Eighteen Novel 2H‐1,4‐Benzoxazin‐3(4H)‐one Containing a Propanolamine Moiety

JR Rao, YF Zhou, X Zhang, XL Zhao - Chemistry & Biodiversity, 2022 - Wiley Online Library
To develop a novel skeleton for broad‐spectrum pesticides with high‐efficiency against tea
tree diseases, a series of aniline 2H‐1, 4‐benzoxazin‐3 (4H)‐one derivatives containing a …

IMesCuCl/TBHP system for aqueous oxidative amidation: Synthesis of new amide derivatives as EGFR targeting anti-breast cancer agents and computational studies

RR Sagam, M Azam, SI Al-Resayes, D Banothu… - Journal of Molecular …, 2024 - Elsevier
A base free and aqueous synthesis of some new 1, 4-benzoxazinone-tetrazole containing
amides via tert‑butyl hydroperoxide (TBHP) mediated oxidative coupling of 2-(5-(2-(3-oxo-2 …

Design and synthesis of some new imidazole-morpholine-1, 2, 4-oxadiazole hybrids as EGFR targeting in vitro anti-breast cancer agents

P kumar Kannekanti, SK Nukala, S Bandari… - Journal of Molecular …, 2024 - Elsevier
Herein, we synthesized some new imidazole-moprholine-1, 2, 4-oxadiazoles (7a-7o) and
characterized their structures using 1 H NMR, 13 C NMR, ESI-mass and CHN analyses …

Ring‐B Modification of Combretastatin A‐4 to Generate Thiazolidine‐2, 4‐dione‐1, 2, 3‐triazole Hybrids as Tubulin Polymerization Inhibitors

A Vanaparthy, K Bokkala, NS Thirukovela… - …, 2023 - Wiley Online Library
In this work we have described the synthesis of thiazolidine‐2, 4‐dione‐1, 2, 3‐triazole
hybrids (7 a–n) via ring‐B modification of Combretastatin A‐4 involving reactions namely …

Synthesis, In Silico Analysis, and Larvicidal Activity of New Bis-oxadiazole Derivatives

R Balije, P Shyam, A Velidandi - Russian Journal of Organic Chemistry, 2023 - Springer
Abstract Twelve new 2, 2′-bi (1, 2, 4-oxadiazole) derivatives containing heterocyclic and
long-chain substituents have been synthesized by the condensation of aldehyde azines and …