Current anti-diabetic agents and their molecular targets: A review
Diabetes mellitus is a medical condition characterized by the body's loss of control over
blood sugar. The frequency of diagnosed cases and consequential increases in medical …
blood sugar. The frequency of diagnosed cases and consequential increases in medical …
C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential
E Bokor, S Kun, D Goyard, M Toth, JP Praly… - Chemical …, 2017 - ACS Publications
This Review summarizes close to 500 primary publications and surveys published since
2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het) arenes. A …
2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het) arenes. A …
Visible light-mediated organophotocatalyzed C–H bond functionalization reactions
M Uygur, OG Mancheño - Organic & Biomolecular Chemistry, 2019 - pubs.rsc.org
Over the last decade, a variety of methodologies for the direct functionalization of C–H
bonds have been developed. Among others, visible light photoredox reactions have recently …
bonds have been developed. Among others, visible light photoredox reactions have recently …
In the search of glycoside-based molecules as antidiabetic agents
A Pałasz, D Cież, B Trzewik, K Miszczak, G Tynor… - topics in current …, 2019 - Springer
This review is an effort to summarize recent developments in synthesis of O-glycosides and
N-, C-glycosyl molecules with promising antidiabetic potential. Articles published after 2000 …
N-, C-glycosyl molecules with promising antidiabetic potential. Articles published after 2000 …
Palladium-Catalyzed Direct C–H Glycosylation of Free (N-H) Indole and Tryptophan by Norbornene-Mediated Regioselective C–H Activation
We describe the palladium-catalyzed direct C–H glycosylation of free NH indole or
tryptophan for the stereoselective synthesis of 2-glycosylindoles and tryptophan-C …
tryptophan for the stereoselective synthesis of 2-glycosylindoles and tryptophan-C …
General Approach to Five-Membered Nitrogen Heteroaryl C-Glycosides Using a Palladium/Copper Cocatalyzed C–H Functionalization Strategy
S Zhang, YH Niu, XS Ye - Organic letters, 2017 - ACS Publications
A general approach to the synthesis of diverse heteroaryl-C-Δ1, 2-glycosides has been
developed by employing the Pd (OAc) 2/CuI cocatalyzed direct cross-coupling of five …
developed by employing the Pd (OAc) 2/CuI cocatalyzed direct cross-coupling of five …
In vitro and in silico studies of mangiferin from Aphloia theiformis on key enzymes linked to diabetes type 2 and associated complications
Background: Mangiferin, was identified in the crude methanol extract, ethyl acetate, and n-
butanol fractions of Aphloia theiformis (Vahl.) Benn. Objective: This study aimed to analyze …
butanol fractions of Aphloia theiformis (Vahl.) Benn. Objective: This study aimed to analyze …
Glycogen phosphorylase revisited: extending the resolution of the R-and T-state structures of the free enzyme and in complex with allosteric activators
The crystal structures of free T-state and R-state glycogen phosphorylase (GP) and of R-
state GP in complex with the allosteric activators IMP and AMP are reported at improved …
state GP in complex with the allosteric activators IMP and AMP are reported at improved …
A multidisciplinary study of 3-(β-d-glucopyranosyl)-5-substituted-1, 2, 4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis …
S Kun, J Begum, E Kyriakis, ECV Stamati… - European journal of …, 2018 - Elsevier
(β-d-Glucopyranosyl)-5-substituted-1, 2, 4-triazoles have been revealed as an effective
scaffold for the development of potent glycogen phosphorylase (GP) inhibitors but with the …
scaffold for the development of potent glycogen phosphorylase (GP) inhibitors but with the …
Multiple pharmacological targets, cytotoxicity, and phytochemical profile of Aphloia theiformis (Vahl.) Benn.
Abstract Aphloia theiformis (Vahl.) Benn.(AT) is traditionally used in Sub-Saharan African
countries including Mauritius as a biomedicine for the management of several diseases …
countries including Mauritius as a biomedicine for the management of several diseases …