What changes in brain function cause the debilitating symptoms of depression? Can we use
the answers to this question to invent more effective, faster acting antidepressant drug …

Cravings that precede loss of control (LOC) over food consumption present an opportunity
for intervention in patients with the binge eating disorder (BED). In this pilot study, we used …

The nucleus accumbens (NAc) is critical in mediating reward seeking and is also involved in
negative emotion processing, but the cellular and circuitry mechanisms underlying such …

Eating disorders are multifactorial disorders that involve maladaptive feeding behaviors.
Binge eating disorder (BED), the most prevalent of these in both men and women, is …

Feeding behavior is regulated by both the homeostatic needs of the body and hedonic
values of the food. Easy access to palatable energy-dense foods and the consequent …

Overconsumption of palatable food may initiate neuroadaptive responses in brain reward
circuitry that may contribute to eating disorders. Here we report that high-fat diet (HFD) …

Dopamine (DA) signal play pivotal roles in regulating motivated behaviors, including feeding
behavior, but the role of midbrain DA neurons in modulating food intake and neural circuitry …

Background Obesity is a chronic relapsing disorder that is caused by an excess of caloric
intake relative to energy expenditure. There is growing recognition that food motivation is …

Feeding behaviour is influenced by two primary factors: homoeostatic needs driven by
hunger and hedonic desires for pleasure even in the absence of hunger. While efficient …

Impulsive overeating is a common, disabling feature of eating disorders. Both continuous
deep brain stimulation (DBS) and responsive DBS, which limits current delivery to …