Reactive astrocyte nomenclature, definitions, and future directions
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling …
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling …
Reactive astrocytes: production, function, and therapeutic potential
SA Liddelow, BA Barres - Immunity, 2017 - cell.com
Astrocytes constitute approximately 30% of the cells in the mammalian central nervous
system (CNS). They are integral to brain and spinal-cord physiology and perform many …
system (CNS). They are integral to brain and spinal-cord physiology and perform many …
Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
Glioblastomas harbor diverse cell populations, including rare glioblastoma stem cells
(GSCs) that drive tumorigenesis. To characterize functional diversity within this population …
(GSCs) that drive tumorigenesis. To characterize functional diversity within this population …
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2− production
Although the pathological contributions of reactive astrocytes have been implicated in
Alzheimer's disease (AD), their in vivo functions remain elusive due to the lack of …
Alzheimer's disease (AD), their in vivo functions remain elusive due to the lack of …
Crosstalk between astrocytes and microglia: an overview
A Matejuk, RM Ransohoff - Frontiers in immunology, 2020 - frontiersin.org
Based on discoveries enabled by new technologies and analysis using novel computational
tools, neuroscience can be re-conceived in terms of information exchange in dense …
tools, neuroscience can be re-conceived in terms of information exchange in dense …
[HTML][HTML] Glial cells and their function in the adult brain: a journey through the history of their ablation
S Jäkel, L Dimou - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Glial cells, consisting of microglia, astrocytes and oligodendrocyte lineage cells as their
major components, constitute a large fraction of the mammalian brain. Originally considered …
major components, constitute a large fraction of the mammalian brain. Originally considered …
Astrocyte-immune cell interactions in physiology and pathology
Astrocytes play both physiological and pathological roles in maintaining central nervous
system (CNS) function. Here, we review the varied functions of astrocytes and how these …
system (CNS) function. Here, we review the varied functions of astrocytes and how these …
Questions and (some) answers on reactive astrocytes
C Escartin, O Guillemaud, M Carrillo‐de Sauvage - Glia, 2019 - Wiley Online Library
Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes
react to virtually all types of pathological alterations in brain homeostasis by significant …
react to virtually all types of pathological alterations in brain homeostasis by significant …
Astrocytes: a central element in neurological diseases
The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …
primary component in the pathogenesis of neurological diseases. As this concept is …
The diversity and disparity of the glial scar
Injury or disease to the CNS results in multifaceted cellular and molecular responses. One
such response, the glial scar, is a structural formation of reactive glia around an area of …
such response, the glial scar, is a structural formation of reactive glia around an area of …