The BET family in immunity and disease

N Wang, R Wu, D Tang, R Kang - Signal transduction and targeted …, 2021 - nature.com
Innate immunity serves as the rapid and first-line defense against invading pathogens, and
this process can be regulated at various levels, including epigenetic mechanisms. The …

Translating therapeutic microgels into clinical applications

Y Kittel, AJC Kuehne… - Advanced Healthcare …, 2022 - Wiley Online Library
Microgels are crosslinked, water‐swollen networks with a 10 nm to 100 µm diameter and
can be modified chemically or biologically to render them biocompatible for advanced …

Materials promoting viral gene delivery

K Kaygisiz, CV Synatschke - Biomaterials Science, 2020 - pubs.rsc.org
Therapeutic viral gene delivery is an emerging technology which aims to correct genetic
mutations by introducing new genetic information to cells either to correct a faulty gene or to …

[HTML][HTML] Lung cancer and oncolytic virotherapy——enemy's enemy

Z Li, Z Feiyue, L Gaofeng, L Haifeng - Translational Oncology, 2023 - Elsevier
Lung cancer is one of the malignant tumors that seriously threaten human health worldwide,
while the covid-19 virus has become people's nightmare after the coronavirus pandemic …

Nanoassembly with self-regulated magnetic thermal therapy and controlled immuno-modulating agent release for improved immune response

M Gao, K Feng, X Zhang, Y Ruan, G Zhao, H Liu… - Journal of Controlled …, 2023 - Elsevier
Cancer immunotherapy is an emerging cancer therapeutic method by activating the patient's
immune system but suffers from low immunogenicity at tumor sites. Fever-like heat is known …

Nitric oxide polymersome-immobilized hydrogels for prevention of post-surgical tumor recurrence and metastasis

L Gao, Z Yuan, N Ma, X Zhou, X Huang, W Chen… - Chemical Engineering …, 2024 - Elsevier
Surgical resection is the primary means of tumor treatment. However, postoperative tumors
are prone to recurrence and metastasis due to residual tumor cells and complicated post …

Enzyme-responsive micellar JQ1 induces enhanced BET protein inhibition and immunotherapy of malignant tumors

Z Zhang, Q Zhang, J Xie, Z Zhong, C Deng - Biomaterials Science, 2021 - pubs.rsc.org
Bromodomain and extra-terminal (BET) proteins are attractive targets for treating various
malignancies including melanoma. The inhibition of BET bromodomains, eg with JQ1, is …

Recent advances in microfluidic-based cancer immunotherapy-on-a-chip strategies

TK Ngan Ngo, CH Kuo, TY Tu - Biomicrofluidics, 2023 - pubs.aip.org
Despite several extraordinary improvements in cancer immunotherapy, its therapeutic
effectiveness against many distinct cancer types remains mostly limited and requires further …

Gelatin methacryloyl granular scaffolds for localized mRNA delivery

BG Carvalho, A Nakayama, H Miwa, SW Han… - …, 2024 - Wiley Online Library
Messenger RNA (mRNA) therapy is the intracellular delivery of mRNA to produce desired
therapeutic proteins. Developing strategies for local mRNA delivery is still required where …

[HTML][HTML] Progress in oncolytic viruses modified with nanomaterials for intravenous application

L Chen, Z Ma, C Xu, Y Xie, D Ouyang… - Cancer Biology & …, 2023 - ncbi.nlm.nih.gov
In oncolytic virus (OV) therapy, a critical component of tumor immunotherapy, viruses
selectively infect, replicate within, and eventually destroy tumor cells. Simultaneously, this …