Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 …
F Vanweert, P Schrauwen, E Phielix - Nutrition & diabetes, 2022 - nature.com
Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
Branched chain amino acids
Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here
the fundamentals of BCAA metabolism in mammalian physiology. Decades of studies have …
the fundamentals of BCAA metabolism in mammalian physiology. Decades of studies have …
[HTML][HTML] FGF21: an emerging therapeutic target for non-alcoholic steatohepatitis and related metabolic diseases
EJ Tillman, T Rolph - Frontiers in endocrinology, 2020 - frontiersin.org
The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …
A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes
F Vanweert, M Neinast, EE Tapia… - Nature …, 2022 - nature.com
Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin
resistance and type 2 diabetes (T2D). Pre-clinical models suggest that lowering BCAA levels …
resistance and type 2 diabetes (T2D). Pre-clinical models suggest that lowering BCAA levels …
Myocardial metabolomics of human heart failure with preserved ejection fraction
Background: The human heart primarily metabolizes fatty acids, and this decreases as
alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with …
alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with …
Fibroblast growth factor 21—metabolic role in mice and men
H Staiger, M Keuper, L Berti… - Endocrine …, 2017 - academic.oup.com
Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance
Elevated levels of plasma branched-chain amino acids (BCAAs) have been associated with
insulin resistance and type 2 diabetes since the 1960s. Pharmacological activation of …
insulin resistance and type 2 diabetes since the 1960s. Pharmacological activation of …
Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity
BACKGROUND Data from studies conducted in rodent models have shown that decreased
adipose tissue (AT) oxygenation is involved in the pathogenesis of obesity-induced insulin …
adipose tissue (AT) oxygenation is involved in the pathogenesis of obesity-induced insulin …
Branched chain amino acids in metabolic disease
Abstract Purpose of Review Elevations in circulating branched chain amino acids (BCAAs)
have gained attention as potential contributors to the development of insulin resistance and …
have gained attention as potential contributors to the development of insulin resistance and …
Branched-chain amino acids and insulin resistance, from protein supply to diet-induced obesity
JP De Bandt, X Coumoul, R Barouki - Nutrients, 2022 - mdpi.com
For more than a decade, there has been a wide debate about the branched-chain amino
acids (BCAA) leucine, valine, and isoleucine, with, on the one hand, the supporters of their …
acids (BCAA) leucine, valine, and isoleucine, with, on the one hand, the supporters of their …