Ari Helenius launched the field of enveloped virus fusion in endosomes with a seminal
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …

There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …

Monoclonal antibodies can provide important pre-or post-exposure protection against
infectious disease for those not yet vaccinated or in individuals that fail to mount a protective …

Cholesterol serves critical roles in enveloped virus fusion by modulating membrane
biophysical properties. The glycoprotein (GP) of Ebola virus (EBOV) promotes fusion in the …

Ebola virus (EBOV) belongs to the Filoviridae family of negative-sense RNA viruses. Since
its identification in 1976, sporadic outbreaks have occurred in Central Africa. The 2014 …

Ion channels are necessary for correct lysosomal function including degradation of cargoes
originating from endocytosis. Almost all enveloped viruses, including coronaviruses (CoVs) …

Ebolavirus, a deadly hemorrhagic fever virus, was thought to enter cells through
endolysosomes harboring its glycoprotein receptor, Niemann-Pick C1. However, an …

SARS‐CoV‐2 may enter target cells through the process of membrane fusion at either the
plasma (~ pH 7.4–7.0) or endosomal (~ pH 6.5–5.0) membrane in order to deliver its genetic …

Ebolavirus (EBOV), an enveloped filamentous RNA virus causing severe hemorrhagic fever,
enters cells by macropinocytosis and releases its genetic material into the cytoplasm after …

Ebola virus (EBOV) makes extensive and intricate use of host factors in the cellular
endosomal/lysosomal pathway to release its genome into the cytoplasm and initiate …