Extended spectrum β-lactamase (ESBL)-producing bacteria are prevalent worldwide and
correlated with hospital infections, but they have been evolving as an increasing cause of …

Escherichia coli is a versatile commensal and pathogenic member of the human microflora.
As the primary causative pathogen in urosepsis, E. coli places an immense burden on …

The Escherichia coli that produces extended-spectrum lactamases (ESBL-E. coli) can
develop resistance to many antibiotics. The control of ESBL-E. coli disorders is challenging …

Background After the MERINO trial with piperacillin/tazobactam, the efficacy of β-
lactam/tazobactam combinations in serious infections involving extended-spectrum β …

Bloodstream infections (BSI) caused by antimicrobial-resistant (AMR) Gram-negative
bacteria (GNB) are a significant cause of morbidity and mortality. Third-generation …

This study evaluated the treatments, mortality rate and patient-related factors associated with
mortality. This is a retrospective study involving hospitalised patients with infections caused …

There is an urgent need for oral agents to combat resistant Gram-negative pathogens. Here,
we describe the characterization of VNRX-5236, a broad-spectrum boronic acid β-lactamase …

Whether the risk of multidrug-resistant bacteria (MDRB) acquisition in the intensive care unit
(ICU) is modified by the COVID-19 crisis is unknown. In this single center case control study …

Background Advances in the diagnostic and therapeutic management of patients with
bloodstream infections (BSIs) have been achieved in the last years, improving clinical …

This study reports the effect of implementing an antibiotic stewardship program (ASP) based
on the “handshake” strategy for 2 years on multiple endpoints compared with that in a …