The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …

The inflammatory response involves the activation of several cell types to fight insults
caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand …

Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

Abstract Silent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has
an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a …

Significance: Antioxidant and redox signaling (ARS) events are regulated by critical
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …

Type 2 alveolar epithelial cells (AEC2s) function as progenitor cells in the lung. We have
shown previously that failure of AEC2 regeneration results in progressive lung fibrosis in …

It is well documented that the rate of aging can be slowed, but it remains unclear to which
extent aging-associated conditions can be reversed. How the interface of immunity and …

Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we
determine the time and dose-dependent effects of NR on blood NAD+ metabolism in …