Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry
Neuromelanin-sensitive MRI is a burgeoning non-invasive neuroimaging method with an
increasing number of applications in psychiatric research. This MRI modality is sensitive to …
increasing number of applications in psychiatric research. This MRI modality is sensitive to …
Neuromelanin-Sensitive MRI: A Biomarker for Treatment-Resistant Schizophrenia?
LJ Vano, M Veronese… - American Journal of …, 2024 - Am Psychiatric Assoc
Approximately one-third of patients with schizophrenia do not receive meaningful benefits
from first-line antipsychotics (1). When this occurs despite two or more adequate treatment …
from first-line antipsychotics (1). When this occurs despite two or more adequate treatment …
Fronto-striato-thalamic circuit connectivity and neuromelanin in schizophrenia: an fMRI and neuromelanin-MRI study
Abstract Changes in dopamine and fronto-striato-thalamic (FST) circuit functional
connectivity are prominent in schizophrenia. Dopamine is thought to underlie connectivity …
connectivity are prominent in schizophrenia. Dopamine is thought to underlie connectivity …
[HTML][HTML] Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-Sensitive Magnetic Resonance Imaging and [18F]-DOPA …
Background Striatal hyperdopaminergia is implicated in the pathoetiology of schizophrenia,
but how this relates to dopaminergic midbrain activity is unclear. Neuromelanin (NM) …
but how this relates to dopaminergic midbrain activity is unclear. Neuromelanin (NM) …
Advances in Understanding Schizophrenia, ADHD, and ASD
NH Kalin - American Journal of Psychiatry, 2024 - Am Psychiatric Assoc
This issue of the Journal focuses on illnesses that are characterized by altered
neurodevelopmental processes: attention deficit hyperactivity disorder (ADHD), autism …
neurodevelopmental processes: attention deficit hyperactivity disorder (ADHD), autism …
[HTML][HTML] Glutamate and GABA levels in the anterior cingulate cortex in treatment resistant first episode psychosis patients
M van der Pluijm, M Alting, A Schrantee… - Schizophrenia …, 2024 - Elsevier
Background Around 30% of schizophrenia patients do not respond sufficiently to
conventional antipsychotic treatment. Glutamate and γ-aminobutyric acid (GABA) may be …
conventional antipsychotic treatment. Glutamate and γ-aminobutyric acid (GABA) may be …
[HTML][HTML] Striatal dopamine synthesis capacity and neuromelanin in the substantia nigra: A multimodal imaging study in schizophrenia and healthy controls
CFM van Hooijdonk, M van der Pluijm, C Smith… - Neuroscience …, 2023 - Elsevier
Abstract [18 F] F-DOPA PET is an established in-vivo method for investigating striatal
dopamine synthesis capacity (DSC) and has demonstrated abnormalities in striatal DSC in …
dopamine synthesis capacity (DSC) and has demonstrated abnormalities in striatal DSC in …
Evidence for Locus Coeruleus–Norepinephrine System Abnormality in Military Posttraumatic Stress Disorder Revealed by Neuromelanin-Sensitive Magnetic …
Background The complex neurobiology of posttraumatic stress disorder (PTSD) calls for the
characterization of specific disruptions in brain functions that require targeted treatment. One …
characterization of specific disruptions in brain functions that require targeted treatment. One …