The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic,
permeable barrier allowing for selective absorption of nutrients, while restricting access to …

Epithelial tight junctions (TJs) are the key structures regulating paracellular trafficking of
macromolecules. The TJ is multi-protein complex that forms a selective permeable seal …

Cell-cell adhesions are critical for the development and maintenance of tissues. Present at
sites of cell-cell contact are the adherens junctions and tight junctions. The adherens …

The gastrointestinal epithelium forms the boundary between the body and external
environment. It effectively provides a selective permeable barrier that limits the permeation …

Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …

The tight junction creates an intercellular barrier limiting paracellular movement of solutes
and material across epithelia. Currently many proteins have been identified as components …

The human intestinal epithelium is formed by a single layer of epithelial cells that separates
the intestinal lumen from the underlying lamina propria. The space between these cells is …

The intestinal epithelium is a single-cell layer that constitutes the largest and most important
barrier against the external environment. It acts as a selectively permeable barrier …