New insights into the differentiation of megakaryocytes from hematopoietic progenitors
LJ Noetzli, SL French, KR Machlus - … , thrombosis, and vascular …, 2019 - Am Heart Assoc
Megakaryocytes are hematopoietic cells, which are responsible for the production of blood
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …
Molecular and cellular mechanisms that regulate human erythropoiesis
AL Caulier, VG Sankaran - Blood, The Journal of the American …, 2022 - ashpublications.org
To enable effective oxygen transport,∼ 200 billion red blood cells (RBCs) need to be
produced every day in the bone marrow through the fine-tuned process of erythropoiesis …
produced every day in the bone marrow through the fine-tuned process of erythropoiesis …
CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information
A goal of single-cell genome-wide profiling is to reconstruct dynamic transitions during cell
differentiation, disease onset and drug response. Single-cell assays have recently been …
differentiation, disease onset and drug response. Single-cell assays have recently been …
[HTML][HTML] DoubletDecon: deconvoluting doublets from single-cell RNA-sequencing data
Methods for single-cell RNA sequencing (scRNA-seq) have greatly advanced in recent
years. While droplet-and well-based methods have increased the capture frequency of cells …
years. While droplet-and well-based methods have increased the capture frequency of cells …
Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development
Human hematopoiesis is a dynamic process that starts in utero 18–21 days post-conception.
Understanding the site-and stage-specific variation in hematopoiesis is important if we are to …
Understanding the site-and stage-specific variation in hematopoiesis is important if we are to …
Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans
Rare hematopoietic stem and progenitor cell (HSPC) pools outside the bone marrow (BM)
contribute to blood production in stress and disease but remain ill-defined. Although …
contribute to blood production in stress and disease but remain ill-defined. Although …
Megakaryocyte and platelet transcriptomics for discoveries in human health and disease
P Davizon-Castillo, JW Rowley… - … thrombosis, and vascular …, 2020 - Am Heart Assoc
Anucleate platelets, long viewed as merely cell fragments with a limited repertoire of rapid-
acting hemostatic functions, are now recognized to have a complex and dynamic …
acting hemostatic functions, are now recognized to have a complex and dynamic …
Perspectives of current understanding and therapeutics of Diamond-Blackfan anemia
Y Liu, S Karlsson - Leukemia, 2024 - nature.com
Diamond-Blackfan anemia (DBA) is a rare congenital bone marrow failure disorder
characterized by erythroid hypoplasia. It primarily affects infants and is often caused by …
characterized by erythroid hypoplasia. It primarily affects infants and is often caused by …
Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice
The mechanisms underlying thrombocytosis in patients with iron deficiency anemia remain
unknown. Here, we present findings that support the hypothesis that low iron biases the …
unknown. Here, we present findings that support the hypothesis that low iron biases the …
Comprehensive phenotyping of erythropoiesis in human bone marrow: evaluation of normal and ineffective erythropoiesis
Identification of stage‐specific erythroid cells is critical for studies of normal and disordered
human erythropoiesis. While immunophenotypic strategies have previously been developed …
human erythropoiesis. While immunophenotypic strategies have previously been developed …