In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

Transgenerational epigenetic inheritance in mammals remains a debated subject. Here, we
demonstrate that DNA methylation of promoter-associated CpG islands (CGIs) can be …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

In mammals, extensive chromatin reorganization is essential for reprogramming terminally
committed gametes to a totipotent state during preimplantation development. However, the …

Abstract H3K9me3-dependent heterochromatin is a major barrier of cell fate changes that
must be reprogrammed after fertilization. However, the molecular details of these events are …

The hypothesis that offspring are affected by parental trauma or stress exposure, first noted
anecdotally, is now supported empirically by data from Holocaust survivor offspring cohorts …

Expression from both alleles is generally observed in analyses of diploid cell populations,
but studies addressing allelic expression patterns genome-wide in single cells are lacking …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

The reprogramming of parental methylomes is essential for embryonic development. In
mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted …