Levodopa, a dopamine precursor, is an effective and well-tolerated dopamine replacement
agent used to treat Parkinson's disease (PD). Oral levodopa has been widely used for over …

Traumatic events can engender persistent excessive fear responses to trauma reminders
that may return even after successful treatment. Extinction, the laboratory analog of behavior …

Abstract Background and Objectives Opicapone is a novel catechol-O-methyltransferase
(COMT) inhibitor. The purpose of this study was to evaluate the tolerability …

Adjunction of the catechol-O-methyltransferase (COMT) inhibitor entacapone (EN) to
levodopa/carbidopa (LD/CD) improves motor symptoms in patients with Parkinson disease …

BACKGROUND AND PURPOSE: Restless legs syndrome (RLS) has a circadian component
with symptoms being prominent at night. The dopaminergic (DAergic) system, which plays a …

Dopamine dysfunction is associated with a wide range of neuropsychiatric disorders
commonly treated pharmacologically or invasively. Recent studies provide evidence for a …

Long-term treatment of l-dopa for Parkinson's disease (PD) patients induces adverse effects,
including dyskinesia, on–off and wearing-off symptoms. However, the cause of these side …

L-3, 4-Dihydroxyphenylalanine [2-amino-3-(3, 4-dihydroxyphenyl) propanoic acid (L-DOPA)
is a natural constituent of animal and plant tissue derived from post-translational …

A chemometrics-assisted spectrophotometric method was developed and validated for the
simultaneous determination of levodopa and carbidopa in pharmaceutical preparations …

Abstract Levodopa/carbidopa (LD/CD) application elevates total plasma homocysteine
(thcys). We determined thcys-, LD-and 3-O-methyldopa (3-OMD) concentrations in 28 …